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- Diploid somatic cells of elephants have 56 chromosomes. If nondisjunction of one of a male elephant’s chromosomes occurs in meiosis II, at the end of meiosis the four resulting sperm are expected to have the chromosome complement:An individual heterozygous for a reciprocal translocation possesses the following chromosomes: A B • C D E F G A B • C D V W X R S • T U E F G R S • T U V W X Q. Draw the pairing arrangement of these chromosomes in prophase I of meiosis.On rare occasions, people are born with a condition known as uniparental disomy. It happens when an individual inherits both copies of achromosome from one parent and no copies from the other parent. Thisoccurs when two abnormal gametes happen to complement each otherto produce a diploid zygote. For example, an abnormal sperm thatlacks chromosome 15 could fertilize an egg that contains two copies ofchromosome 15. In this situation, the individual has maternal uniparental disomy 15 because both copies of chromosome 15 were inheritedfrom the mother. Alternatively, an abnormal sperm with two copies ofchromosome 15 could fertilize an egg with no copies. This is known aspaternal uniparental disomy 15. If a female is born with paternal uniparental disomy 15, would you expect her to be phenotypically normal,have Angelman syndrome (AS), or have Prader-Willi syndrome(PWS)? Explain. Would you expect her to produce normal offspring oroffspring affected with AS or PWS?
- An individual is heterozygous for a reciprocal translocation, with the following chromosomes: A • B C D E F A • B C V W X R ST • U D E F R ST • U V W X Q. Draw a picture of these chromosomes pairing in prophase I of meiosis.Structurally, meiotic cohesins have different components than mitotic cohesins. This leads to what function differences?Variations in Chromosome NumberAneuploidy Describe the process of nondisjunction and explain when it takes place during cell division.
- A human female with Turner syndrome (45,X) alsoexpresses the X-linked trait hemophilia, as did her father.Which of her parents underwent nondisjunction during meiosis,giving rise to the gamete responsible for the syndrome?A female is heterozygous for an X-linked gene. If nondisjunction happens for the sex chromosomes during Meiosis II, one aneuploid gamete would contain: two copies of the X chromosome that are identical two copies of the X chromosome that are not identical two copies of the X chromosome that are identical and a Y chromosome an X chromosome and a Y chromosomeExplain why a person with Klinefelter Syndrome (XXY) still exhibits abnormal phenotypes despite the fact that one of the extra X Chromosome is inactivated practically leaving an XY active sex chromosomes similar to a normal male?
- A human female with Turner syndrome (45,X) also expresses the X-linked trait hemophilia, as did her father. Which of her parents underwent nondisjunction during meiosis, giving rise to the gamete responsible for the syndrome?X chromosome inactivation in a diploid XX female is not completely inactivated, explain?Barr bodies are formed to adjust X chromosome dosage in species other than humans, such as Drosophila (fruit flies) and C. elegans (nematodes). True or False ?