The head of the oncology divison of a large biotech company proposes to develop a therapeutic antibody to treat cancers with mutant B-Raf oncogene. Is this a good idea? Why or why not(limit 3-4 sentences)?
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The head of the oncology divison of a large biotech company proposes to develop a therapeutic antibody to treat cancers with mutant B-Raf oncogene. Is this a good idea? Why or why not(limit 3-4 sentences)?
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- One of the following sentences is NOT correct A. P53 is an example of tumour suppressor gene B. Wright's stain is sued to visualize a peripheral blood smear C. leukotrienes are derived from arachidonic acid by cyclooxygenase D. effective bacteriocidal enzymes are contained in lysosome of the neutrophils E. H&E stain is the most commonly used tissue stain for routine histological examination F. proteoglycans are located in the ECM but not in the ground substance of connective tissue Mr. Yeboah, diagnosed with a malignant tumour of the liver had it removed and was given a course of chemotherapy. Initially, tumour marker (AFP) activity activity was 7500KU/L (which is very high) but after treatment, this gradually declined to only 5KU/L. A routine follow up test was perfomedafter 3 months and the results was 15KU/L for AFP. The doctor suspected a relapse of the tumour and so referred Mr. Yeboahto an oncologist at a cancer centre who also did a re-check. AFP was recorded to be 5KU/L. Enquiries revealed that the hospital and the cancer centre use different instruments for the measurement of AFP. Both results are normal even though the values are significantly different because different methods were used.a) How can both labs confirm that the results are not clinically significant? b) How can both labs avoid this happening again?what are the consequences of anemia and leukopenia during chemotherapy
- A young child with cretins is not growing and parents would like her to take synthetic hGH. Will this treatment help the child. Explain your answerA 3-year-old girl was admitted with a diagnosis of acute lymphocytic leukemia. After admission, she was treated by administration of packed red cells, 2 units of platelets, IV fluids, and allopurinol. On the second hospital day, chemotherapy was begun, using IV vincristine and prednisone and intrathecal injections of methotrexate, prednisone, and cytosine arabinoside. She was discharged for home care 5 days later. She was continued on prednisone and allopurinol at home. She received additional chemotherapy 1 month later (11/1) and again on 11/14. On 12/6, she was readmitted because she had painful sores in her mouth and was unable to eat. LABORATORY RESULTS 10/1 10/2 10/3 10/4 11/14 12/6 6/20 Urea N 12.0 ** ** 15 4.0 2.0 ** (mg/dL) Creatinine 0.7 (mg/dL) 0.7 0.7 ** ** 1.0 ** Uric acid (mg/dL) 9.2 ** 12.0 4.0 1.9 2.3 3.1 WBC 56,300 3,700 ** ** ** 2,800 3,700 (mm2) **indicates test not performed Questions: 1. How would you explain the significant elevations of uric acid on admission? 2.…What is monoclonal antibodies? How it can be categorized. (Subject: Biotechnology)
- You are interested in performing indirect immunofluorescence light microscopy to observe the localization of the catalase enzyme in the cultured HeLa cells, obtained historically from the cervical tumor of Henrietta Lacks. You were going through the lab stock and found a few primary and secondary antibodies. Which of the following secondary antibody can you use in your experiments? O All of the mentioned antibodies can be used in the experiment Goat anti-human antibody conjugated to 10 nm gold Goat-anti-human catalase conjugated to 10 nm gold O Human anti-catalase antibody conjugated to fluorescent rhodamine Goat anti-human antibody conjugated to fluorescent rhodamine2. https://doi.org/10.1186/s12868-022-00692-1 (link to research) a) In the immunohistochemistry section of the materials and methods section the authors wrote “The number of positive cells in hotspot areas in ten high power fields (HPFs) in areas of demyelination and plaques in the brain stem were counted using the image analysis software (Lecia Application Suite Version 4.12.0, Welzlar, Germany).” Why were they looking at demyelination areas for this study? b) In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “Active plaques revealed inflammatory cellular infiltrates with abundant macrophages stuffed with myelin debris, an evidence of ongoing myelin breakdown.” What does macrophages stuffed with myelin debris have to do with the study?Immunocompromised patients are at a higher risk of cancer. Discuss how the immune system plays a role in this.
- This is homework not a test! From NTSA case study https://static.nsta.org/case_study_docs/case_studies/cystic_fibrosis.pdf Please help with questions 2, 3 and 4 of part four 2. "The successful use of gene therapy to cure SCID syndrome (2000) is hoped to be a permanent cure for those patients because a good copy of the problem gene was inserted into the patients' blood stem cells in the bone marrow (hematopoietic stem cells). Once white blood cells enter the blood stream they have a limited life span, on the order of a few week to months. The blood stem cells are the cells that create more white blood cells to replace those that are lost. If the gene was only inserted into the circulating mature white blood cells, the patient would only be temporarily cured until those cells were used up or died." The current gene therapy approaches to cure CF involve inserting a functional CFTR gene into the mature epithelial cells of the lungs. In light of the preceding paragraph, do you think that…hi, can I please get help on a case study on nueroanatomy I have been struggling for a couple of hours now and can't seem to understand the study to answer the following questions. is there any way or format that i can get help. I would really appreciate it. thanks! 1. Based on the information in the case, what is the most likely neuroanatomic location for a single lesion that can explain all of the patient’s symptoms and signs? In your own words, explain how you arrived at that localization. 2.What are some possibilities for the nature of the lesion (e.g., stroke, tumor, trauma, etc.)? In your own words, explain your rationale for these options. 3. How does the laboratory data and neuroimaging demonstrate the actual lesion for the patient? Describe how you interpret the data in your own words. 4.How was the patient was treated, and how did they subsequently fare? Describe the treatment plan in your own words.Given the knowledge that cancer cells are continuously dividing and normal cells are not, try to explain how radiotherapy can kill cancer cells more than normal cells.
