The plasma of half-life of aspirin is t1/2 = 20 minutes; ibuprofen t1/2 = 2 hours. Both agents are dosed q 4 to 6 hours. Compared to ibuprofen, APAP's dosing can be much longer than it's plasma half-life because it is: 1. more toxic, so cannot be taken as often 2. more selective for COX1 than is ibuprofen 3. an irreversible inhibitor

The plasma of half-life of aspirin is t1/2 = 20 minutes; ibuprofen t1/2 = 2 hours. Both agents are dosed q 4 to 6 hours. Compared to ibuprofen, APAP's dosing can be much longer than it's plasma half-life because it is: 1. more toxic, so cannot be taken as often 2. more selective for COX1 than is ibuprofen 3. an irreversible inhibitor

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter16: Adult And Pediatric Dosages Based On Body Surface Area

Section: Chapter Questions

Problem 5.1P

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