This is an example of a Base Catylized Nucleophilic Acyl Substitution. Specifically the mechanism is anexample of base catylized alcoholysis analogous to what we have seen with carboxylic acid derivatives.Complete the curved-arrow mechanism for this reaction.NOTE: You can use H-A for acid and :B or -:A for base as needed.:0: Compound A:0: Compound BHH:0:: OMe:OME1)K:0 HH:S:2): CIما: OMe:S:

Answer is given belowExplanation:Step 1: Step 2: Step 3: Step 4:

Answered: This is an example of a Base Catylized…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 4E

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A- What is the definition of acidity? B- Compare the acidity of ammonia and its aliphatic derivatives with of acidity pyrrole C- Melting points of pyrrole is higher than melting point of 1-methyl pyrrole explain your answer D- Why does pyrrole prefer electrophilic substitution reactions? E- Why Pyrrole is considered to be an aromatic compound ? F- Explain the Reimer-Tiemann reaction mechanism of heterocyclic compounds? G- Why pyridine is a weak base? explain your answer? H- Pyridine can react with electrophiles, electrophilic substitution ? explain your answer ? G- Explain the Diels–Alder reaction mechanism of heterocyclic compounds? I- From a-haloketone how can you prepared flowing compounds : Imidazole Oxazole Thiazole J- compared the acidity and basicity of Pyrazole and Imidazole with Pyrrole and Pyridine ?
Provide TWO Grignard reactions, A and B, that can be to make the provided target structure. Give the organic reactant and the Grignard reagent that would be used, yo not need to specify the aqueous acid workup step, but you must specify which of the c-c bonds is being made in the provided traget structure. Ignore stereochemistry in this question.
In synthesis of methyl benzoate by fischer estrification : the teaction is carried out using sulfuric w. Which is true? Both of reactions as well as product are protonated by it during the reaction it is necessary to solubilize the reactants its purpose is to generate a methyl carbocation it acts as a nucleophile
A. Arrange the following radicals in order of decreasing rate of bromination. Justify your answer. B. Trehalose and isomaltose are both dimers of glucose. However, they have considerablydifferent reactivities. Concisely explain why these differences are observed. -Isomaltose is a reducing sugar while trehalose is not.-Trehalose is very resistant to acid hydrolysis while isomaltose can be acid-hydrolyzed withease.
In the Friedel-Crafts alkylation of benzene, dialkylation is often a significant by-product. In the Friedel-Crafts acylation of benzene, diacylation is not a significant by-product. Which of the following is the primary reason for this difference? a. Acyl cations are more difficult to make with Lewis acids b.Unlike acyl cations, carbocations can undergo rearrangements. c.Alkyl groups activate the ring to further substitution, acyl groups deactivate it. d. Alkyl groups activate the ring to further substitution, acyl groups deactivate it
Keeping in mind the mechanism for the dissolving metal reduction of alkynes to trans alkenes, write a stepwise mechanism for the following reaction, which involves the conversion of an α,β- unsaturated carbonyl compound to a carbonyl compound with a new alkyl group on the α carbon.
Rank the following carboxylic scid derivatives in order from LEAST to MOST reactive when they undergo nucleophilic acyl substitution reactions. If two are equal or close, you can use "=". Justify your answer in words - using leaving group ability, base strength, conjugate acid strength, pKa values, etc., if applicable.
OChem help... Complete the following reaction sequence: Indicate regiochemical/stereochemical details as relevant. Provide the stepwise mechanism for the following... (see image)
Arrange the following in order of decreasing reactivity to nucleophilic addition: ketone, aldehyde. Explain your logic.
Explain the reaction for the formation of acetal and hemiacetal. Explain why N,N-disubstituted amide is less acidic than ester. Why only methyl ketone do undergoes haloform reaction. LDA is the base of choice for carbonyl compound to completely convert into enolate. Why?
1) How will you describe whether any compound has been oxidized or reduced? Support the answer with suitable examples. 2)Why carboxylic acid with a carbonyl group at 3rd position can be decarboxylated? 3) Explain why electrophilic aromatic substitution in Pyrrole takes place at C-2 positions whereas, in Pyridine it takes place at C-3 position? 4) List the following esters in order of decreasing reactivities towards hydrolysis with reason: Methyl benzoate, p-cyano methyl benzoate and p-hydroxy methyl benzoate 5)LDA is the base of choice for carbonyl compound to completely convert into enolate. Why?
Provide the curved arrow mechanism of the reaction of 2-ethylcyclopentanone treated with pyrrolidine in aqueous acid.

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