Using cyclopentanone as the reactant, show the product of a. acid-catalyzed keto–enol interconversion. b. an aldol addition. c. an aldol condensation.
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Using cyclopentanone as the reactant, show the product of
a. acid-catalyzed keto–enol interconversion. b. an aldol addition. c. an aldol condensation.
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- draw the reaction scheme and step by step reaction mechanism of the following please. a. williamson ether syhthesis of 4-chlorophenol using reagents K2CO3 and benzyl chloride b. reduction of aldehyde 2-propanol to propanone using reagents NABH4 c. aldol condensation of 4-chlorobenzaldehyde and dimethylmalonate using reagents NaOH and EtOHCompare each of the mechanisms listed here with the mechanism for each of the two parts of the acid-catalyzed hydrolysis of an ester, indicating a. similarities. b. differences. 1. acid-catalyzed formation of a hydrate 2. acid-catalyzed conversion of an aldehyde to a hemiacetal 3. acid-catalyzed conversion of a hemiacetal to an acetal 4. acid-catalyzed hydrolysis of an amideWhat functional group is formed as the final product of an aldol condensation? A. B-hydroxycarbonyl В. a,B-unsaturated carbonyl C. enol D. enolate
- 1. Provide the mechanism of the reaction shown in the picture. 2. Explain why it cannot be done in basic conditions. 3. Why is the enol tautomer favored over the keto tautomer? Ph H3C OH H H3O+/H₂O HO H3C PhSelect the di-carbonyl compound that would efficiently form the structure shown via an intramolecular Aldol reaction. A. or B. •oo •ay E. og F. olDraw the major product of the aldol addition reaction between two equivalents of this ketone with the conditions provided. Ignore inorganic byproducts. 1. NaOH 2. Neutralizing work-up
- Draw the major product of the aldol addition reaction between two of equivalents of this aldehyde with the conditions provided. Ignore inorganic byproducts. 1. H3O+ 2. Neutralizing work-up Drawing H Q1. Provide the mechanism of the reaction shown in the picture. 2. Explain why it cannot be done in basic conditions. 3. Why is the enol tautomer favored over the keto tautomer?1. The molecule below is ascorbic acid, also known as vitamin C. a. As drawn below, ascorbic acid is shown as a diketone. An enol tautomer of ascorbic acid exists and is how the molecule is usually drawn. Draw the enol tautomer of ascorbic acid. b. Show the mechanism for tautomerization under basic conditions from the ketone to the enol. c. Ascorbic acid has a pK₂ of 4.6 which is more similar to that of a carboxylic acid than an alcohol. Which H is most acidic in ascorbic acid? d. Explain why Vitamin C is so acidic. OH OH ascorbic acid OH
- 4. Provide a synthesis of the product shown from starting material using a Wittig at some point in your synthesis. You must show the synthesis of any Wittig reagents from an alkyl halide. You may use any other reasonable reagents necessary. nob synthesis? magno H3C.Compare the mechanisms listed here with the mechanism for the two parts of the acid-catalyzed hydrolysis of an ester, indicatinga. similarities. b. differences. acid-catalyzed conversion of a hemiacetal to an acetal1. For the following reaction step, indicate which pattern of arrow pushing it represents. a. proton transferb. rearrangementc. loss of a leaving group2. Melphalan, a drug used in chemotherapy, reacts with itself in the body before binding with its target, as illustrated in the mechanism below. What is the first pattern of arrow pushing seen in this reaction? a. rearrangementb. loss of a leaving groupc. nucleophilic attack