What would most likely occur to nuclear-cytoplasmic shuttling if the intrinsic GTPase activity of RAN was slowed down by 50%? Group of answer choices RAN would not bind exportin and proteins would accumulate in the nucleus All of the answers are likely None of the answers are likely Importin beta would not release from RAN in the cytoplasm and nuclear import would slow down RAN would not bind to importin beta and protein cargo in the nucleus would not release

What would most likely occur to nuclear-cytoplasmic shuttling if the intrinsic GTPase activity of RAN was slowed down by 50%? Group of answer choices RAN would not bind exportin and proteins would accumulate in the nucleus All of the answers are likely None of the answers are likely Importin beta would not release from RAN in the cytoplasm and nuclear import would slow down RAN would not bind to importin beta and protein cargo in the nucleus would not release

Biology (MindTap Course List)

11th Edition

ISBN:9781337392938

Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Publisher:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg

Chapter6: Cell Communication

Section: Chapter Questions

Problem 4TYU

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What would happen to nuclear transport if you removed all of the Ran-GAP? For a while nuclear import receptors will still deliver cargo to the inside of the nucleus Nuclear import receptors will be loaded with RanGTP and will gradually stop binding to the proteins with NLS signals Nuclear export receptors will no longer deliver their cargo to the outside of the membrane and will probably shuttle in and out of the nucleus full of cargo Ran-GDP will no longer be made All of the above
Which describes an enzymatic activity/biochemical function of importin-beta? facilitate release of nuclear proteins after transport through the nuclear pore complex interact with/bind to nuclear localization sequences INLSS) interact with/bind to importin-alpha hydrolyze GTP to GDP + Pi
Which describes an enzymatic activity/biochemical function of importin-beta? O hydrolyze GTP to GDP + Pi interact with/bind to nuclear localization sequences INLSS) interact with/bind to importin-alpha facilitate release of nuclear proteins after transport through the nuclear pore complex
Cytokine receptors and tyrosine kinase receptors are similar in all of the following ways EXCEPT one. Which one is the exception? O They are both down-regulated by lysosomal degradation They both involve receptor exoplasmic domain dimerization They both result in an effector protein entering the nucleus O They both involve cytosolic domain phosphorylation
Which of the following small GTP-binding proteins does NOT play a role in cell migration during chemotaxis? O Cap Z Rho Cdc42 O All of the listed GTPases play a role in cell migration O Rac ◆ Previous
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# 3 You've engineered a mutant cell where the FADD adapter was truncated. The mutant FADD only contains the Death Domain, and lacks the Death Effector Domain. What is the most likely phenotypic outcome for this mutant cell when presented with the Fas ligand? 20 E O The Fas/FasL oligomer is formed, but apoptosis is blocked O The Fas/FasL oligomer is formed, and apoptosis is hyperactivated O The Fas/FasL oligomer is not formed, and apoptosis is blocked O The Fas/FasL oligomer is not formed, but apoptosis is hyperactivated F3 $ 4 DOD 000 R F4 % 5 F5 T BARAT 6 tv @ MacBook Air F6 Y & 7 F7 U * ➤11 8 F8 · 9 F9
What is the role of the Ran-GAP protein in nuclear transport? Ran-GAP converts RanGTP to RanGDP Ran-GAP is a receptor on the nuclear membrane Ran-GAP is not directly involved in nuclear transport, it is a transcription factor Ran-GAP shuttles between mitochondria and the nucleus Ran-GAP converts RanGDP to RanGTP
Which statement about the M6P receptor is true/accurate? Answers: It is involved in retrieval of ER resident proteins from the Golgi and transport back to the ER. Due to no difference in pH in the lumen of each, it has the same affinity for M6P in the Golgi as in the endosome. Due to a slight difference in pH in the lumen of each, it has a high affinity for M6P in the Golgi and a low affinity for M6P in the endosome. Due to a slight difference in pH in the lumen of each, it has a low affinity for M6P in the Golgi and a high affinity for M6P in the endosome.
Which THREE statements are true about targetting proteins to the nudieus? Aln the cytoplasm, a protein with an appropriate nuclear localization signal (NLS)is brund by a compna sd moint Importins a and B and CAS are degraded in the nucieus The nuclear localization sequence usually contains around 20 ameno aoids The nuclear localization sequence contains severai consecutive basic (Arg or Lysi me The nuclear localization sequence is ocated almost anywhere in protein amino aad sequerce The nuclear localization sequence is emoved after targeting to the nucleus
All are protiens of cell membrane that are involved in flow of nerve impulse except 1-channel proteins 2-carrier protiens 3-peripheral protiens 4-integral protiens Also give explanation
Microtubules are important for transporting cargo in nerve cell axons, as diagrammed in Figure Q17- 33. Notice that the two types of cargo are traveling in opposite directions. Which of the following statements is likely to be false? cell body microtubule axon Figure Q17-33 inward transport axon terminal The black cargo and the gray cargo require ATP hydrolysis for their motion. The gray cargo is attached to dynein. outward transport The black cargo and the gray cargo are moving along microtubules of opposite polarity. The black cargo moving toward the axon terminal contains a domain that specifically interacts with the tail domain of a particular kind of motor.