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- Which of the following is an example of an unacceptable missense? a. HbA is converted to Hb Hikari, where the beta chain Lysine at #61 is replaced by Asparagine. b. Hb A, is converted to Hb M (Boston) where the alpha chain Histidine at #58 is replaced by Tyrosine. c. Hb A is converted to Hb S, where the beta chain Glutamate at #6 is replaced by Valine.Which of the following is false about chymotrypsin? A Hydrolytic cleavage of a peptide bond by chymotrypsin involves two nucleophilic attacks to the substrate B It is activated in the presence of trypsin C It is synthesized in the thyroid gland D Polypeptide chains in chymotrypsin are linked by S-S bondsA biotech company develops a biosensor that measures the presence of proteins activated by growth factor signaling cascades. Which binding domain would you use to each of the following activation peptides or signaling molecules. Phosphotyrosine A. SH2 Domain A peptide with the sequence Arg-Ala-Pro-Pro-Leu- B. Bromodomain Pro C. 14-3-3 Domain ◆ Phosphatidyl inositol Triphosphate (PIP3) Phosphoserine Acetylated Lysine D.PH Domain E. SH3 Domain
- Some are unable to taste thiourea and PTC. DNA sequence results for these individuals show a normal predicted amino acid sequence for the TAS2R38 gene. Provide an explanation that can account for insensitivity to thiourea. (a) First assuming a mutation involving the TAS2R38 gene (b) Then assuming a mutation in a gene other than TAS2R38A. Elastase is activated by trypsinB. Trypsinisactivatedbyelastase Which statement is correct? Proteolytic activation of chymotrypsin from chymotrypsinogen requires cleavage of four peptide bonds. Assume that any proteases can convert 100 substrates to 100 products. Activation of one enteropeptidase can eventually lead to formation of how many chymotrypsin proteins?How is cigarette smoking related to elastase function? Methionine sulfoxide is formed by cigarette smoke in the antitrypsin protein, which leads to the full manifestation of the disease in individuals heterozygous for emphysema. Oxidation of methionine 358 by cigarette smoke of the elastase inhibitor active site leads to an increased inhibition of elastase and subsequent overaccumulation of mucus in the lungs. The inhibitor of elastase is axidized by cigarette smoke so elastase doesn't function properly in healthy individuals. Cigarette smoke modifies the elastase methionine residues such that the enzyme activity is blocked.
- Which of the following best describes the production of insulin in by bacterial cells. The biosynthetic pathway that produces human insulin is introduced into bacterial cells on a plasmid. Insulin is purified from bacterial lysates by electrophoresis. Human insulin in a peptide hormone comprised of two chains A and B. Only B chain is required, It is produced by injecting bacteria with MRNA encoding B chain peptide, and purifying the peptides with an antibody. Fuman insulin in a peptide hormone comprised of two chains A and B. It is produced by injecting bacteria with transgenic plasmids containing MRNA encoding either the A and B chain peptides, and purifying the peptides with a mix of antibodies against tne A or B chain. aman nsulina peptide hormone comprised of two chains A and B. They are produced separately as fusion proteins with beta-galactosidase when bacterial cells are transformed with plasmids containing either A or B chain with the lacZ sequence. Once purified they are…The steps of the chymotrypsin mechanisms are listed below (1-7). Put the steps of chymotrypsin mechanism in the correct order. Figure representing chymotrypsin mechanism is given for reference. a.The portion (N-terminal end) of original substrate with the new C terminus diffuses away b. Substrate binding c. His 57 catalyzes removal of H from Ser 195 hydroxyl; Ser 195’s nucleophilic O attacks carbonyl C of substrate; tetrahedral intermediate is formed d. Water binding; water is deprotonated by His 57; resulting OH nucleophilically attacks carbonyl of remaining substrate; tetrahedral intermediate is formed e. His 57 donates H to N of…The Table below shows the names of proteins whose functions are regulated through the binding of their ligands. Complete this Table by filling in the correct ligands for each of the proteins, the corresponding K, value, the affinity of this protein for its ligand and the source where the protein is found. Example Protein Avidin 1 Insulin receptor 2 Anti-HIV immunoglobulin 3 Nickel binding protein 4 Myoglobin 5 Myosin 6 Acetyl-CoA carboxylase 7 Cannabinoid receptor 1 (CB1) 8 Guanylyl cyclase Ligand Biotin Kd (M) 1 x 10-15 Affinity high Source/Organism Egg white
- Polyethylene glycol (PEG)-conjugated IFNs have superior pharmaceutical properties compared with their unconjugated counterparts as a result of greater protection against proteolytic degradation, better solubility, and slower catabolism and excretion. Group of answer choices True FalseUsing the catalytic mechanism of serine proteases, draw and label a reaction coordinate diagram/graph of the chymotrypsin-catalyzed hydrolysis of a peptide bond.14) Which of the following correctly ranks the steps in the secretory pathway? 1. Active PKA subunits phosphorylate targets in the cell, regulating function. 2. The catalytic subunits of PKA dissociate. 3. Gprotein a subunit exchanges bound GDP for GTP. 4. CAMP binds to the regulatory subunits of PKA, activating it. 5. Ga subunit dissociates from complex and activates adenylate cyclase. 6. Ligand (hormone) binds to receptor. 7. Activated adenylate cyclase produces CAMP from ATP.