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- Your friend sends you two cancerous cel| lines to examine and determine possible mutations. The results are shown below: Cell Line Mutation WT none (wild type DNA) 1 a deletion at the same region on both copies of chromosome 4 2 a point mutation in a gene on only one copy of chromosome 7 You learn that cell line 2 is a breast cancer cell line that expresses a mutant version of a receptor protein called KIT. Based on this data, which of the following is true ? Select all that apply Activation of KIT promotes progression through the cell cycle Activation of KIT releases an inhibition of a cyclin Activation of KIT causes cells to enter GO O Activation of KIT promotes cells to undergo apoptosisYour friend sends you two cancerous cell lines to examine and determine possible mutations. The results are shown below: Cell Line Mutation WT none (wild type DNA) 1 a deletion at the same region on both copies of chromosome 4 a point mutation in a gene on only one copy of chromosome 7 You learn that cell line 2 is a breast cancer cell line that expresses a mutant version of a receptor protein called KIT. Based on this data, which of the following is true ? Select all that apply Activation of KIT promotes progression through the cell cycle V Activation of KIT releases an inhibition of a cyclin Activation of KIT causes cells to enter GO V Activation of KIT promotes cells to undergo apoptosisYour friend sends you two cancerous cell lines to examine and determine possible mutations. The results are shown below: Cell Line Mutation WT none (wild type DNA) 1 a deletion at the same region on both copies of chromosome 4 2 a point mutation in a gene on only one copy of chromosome 7 You learn that cell line 2 is a breast cancer cell line that expresses a mutant version of a receptor protein called KIT. Based on this data, which of the following is true ? Select all that apply Activation of KIT promotes progression through the cell cycle Activation of KIT releases an inhibition of a cyclin Activation of KIT causes cells to enter GO Activation of KIT promotes cells to undergo apoptosis
- The following is true about epigenetic gene control: O epigenetic changes to the chromatin may result from childhood development epigenetic changes to the chromatin may result from chemicals in the environment O epigenetic changes to the chromatin may result in cancer O An example of a chromatin change is DNA methylation that prevents gene expression from that area of the DNAIn humans, dosage compensation is accomplished by: inactivating one X chromosome in female somatic cells inactivating one homolog from each homologous pair of chromosomes in female somatic cells inactivating the Y chromosome in male somatic cells increasing gene expression from the X chromosome in male somatic cellIn mammalian females, the majority of one X chromosome's genes are shut down in a process called X chromosome condensed and afterwards called a The inactive X is Because the shutdown is random in the embryonic cells formed by the time inactivation occurs, all mature mammalian females are a for the expression of X chromosome genes. The inactivation of one X in the female is thought to . The shutdown of the X chromosome is accomplished by the balance gene expression between males and females, a theory called gene. is the master gene for male sex determination in mammals and is found on the human Y-chromosome.
- Which of the following proteins is a combinatorial transcriptional regulator in Drosophila that affects the differentiation of multiple cell types? O the glucocorticoid receptor O MyoD O Ey O Muts O maintenance methyltransferaseRegulation of the cell cycle is very complex and involves multiple proteins. In yeast, a complex of cdc2 and a mitotic cyclin is responsible for moving the cell past the G2/M checkpoint. The activity of the cyclin-dependent kinase cdc2 is inhibited when it is phosphorylated by the kinase, Wee-1. What would you predict would be the phenotype of a Wee-1 mutant yeast? What other genes could be altered in a Wee-1 deficient mutant strain that would make the cells act normally?Gene A encodes for a protein A which prevents exit from the G1 phase of the cell cycle. You are studying mutations in gene A. Which of the following are true for gene A? Select all that apply A mutation that gives constitutively active protein A in one allele and a deletion of the entire gene in the second allele will transform the cell Gene A is a proto-oncogene A nonsense mutation that replaces the fourth codon with a stop codon in one allele and a deletion of the entire gene in the second allele will transform the cell Gene A is a tumor supressor gene
- Your friend sends you two cancerous cell lines to examine and determine possible mutations. The results are shown below: Cell Line Mutation WT none (wild type DNA) 1 a deletion at the same region on both copies of chromosome 4 a point mutation in a gene on only one copy of chromosome 7 Based on this data, what type of geńe is mutated in each of the cell lines? Select all that apply O Cell line 2 has a mutation in an oncogene Cell line 1 has a mutation in a tumor suppressor gene Cell line 1 has a mutation in an proto-oncogene Cell line 2 has a mutation in a tumor suppressor geneWhat is the primary mechanism by which eukaryotes control transcription during cellular differentiation? O Posttranslational control of proteins through ubiquitination and phosphorylation O Regulatory transcription factors that influence chromatin structure and bind to regulatory regions O Inhibition of RNA polymerase through the expression of inhibitory enzymes O Production of microRNAs to disable mRNAs that should not be expressed O Alternative splicing of genes in different tissue typesProtein P, normally stimulates apoptosis or cell death when activated. Consider a cell with a mutation in one allele such that protein P is always expressed and active, while the other allele of gene P is deleted. Which of the following is true for this cell? Gene P is a proto-oncogene, and the phenotype of the cell is transformed. Gene P is a proto-oncogene, and the phenotype of the cell is not transformed. Gene P is a tumor suppressor gene, and the phenotype of the cell is not transformed Gene P is a tumor suppressor gene, and the phenotype of the cell is transformed 로