Which of the following represents an example of a proteoglycan? attachment of several molecules of heparin to the peptide antithrombin II O attachment of a Gal-B(1,3)-GalNAc disaccharide to the fish antifreeze protein O attachment of a small oligosaccharide to an immunoglobulin O attachment of a small antigenic determinant to a membrane bound protein of a cell

Which of the following represents an example of a proteoglycan? attachment of several molecules of heparin to the peptide antithrombin II O attachment of a Gal-B(1,3)-GalNAc disaccharide to the fish antifreeze protein O attachment of a small oligosaccharide to an immunoglobulin O attachment of a small antigenic determinant to a membrane bound protein of a cell

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 7QP

See similar textbooks

Similar questions

(a) Answer all sections (i)- (Iv). Below is given the structure of three anti-HIV drugs: OH Meo. OMe NH Ph Nevirapine Atazanavir Staudivine (i) Give the drug target and discuss the anti-HIV mechanism of each of these drugs. Vaccines are an attractive prophylactic treatment against both viral and bacterial diseases. A number of glycaconjugate vaccines using bacterial polysaccharide structures conjugated to protein carriers have been introduced into mass vaccination schemes with excellent results. What differences are there in the immune response to a glycoconjugate vaccine as compared to a polysaccharide vaccine? These glycoconjugate va nes has been used for 30 years without any change in their structures, while the composition of the flu vaccine, based on attenuated or killed virus particies, is changed from year to year. Discuss the reason behind this. (iv) Discuss why it has not been possible to develop a (part structure) vaccine against the HIV virus, based on either I) viral…
The ACE2 receptor protein in humans has been getting a lot of press these days, as it apparently serves as a "receptor" for the SARS-CoV-2 coronavirus in addition to its normal functions. This protein has an isoelectric pH of 5.36. Suppose you want to purify this protein to study its properties, with the goal of developing a drug that would block it from binding the virus. Once you have purified the cell surface proteins from your cultured human lung cells away from all the other types of molecules in the cell, and all the cytoplasmic proteins, you might decide to use ion exchange chromatography to separate the ACE2 proteins from other proteins in your sample. If you plan to load your protein mixture onto your ion exchange column in a buffer at pH 7.4 (approximately physiological pH) and you want the ACE2 proteins to bind to the column, should you use a resin with a positive charge or a negative charge? Briefly explain why you chose the resin you selected.
Cytokine Storm (Cytokine Storm) COVID-19The high mortality rate in COVID-19 patients is caused by the occurrence of a cytokine storm (cytokine storm) in the patient's body. This is based on research supported by data obtained, among others, from laboratory results; that there was a significant difference between patients who recovered and those who died. What research data? Please Answer these following structured questions; Are cytokines a protein? How many amino acid residues of human cytokines? The sequence of the amino acid residues? Accession number at GenBank ? Determine the mRNA sequence Determine the coding sequence Define the sequence template What is a Cytokine storm What research data support the occurrence of Cytokine storm in humans Answers on paper with source cited provided will be helpful since im new in this part and want to learn from the source you find the answer Thank you
Lamivudine (3TC) An analogue of deoxycytosine, a DNA component Needs to be first phosphorylated by cellular deoxycytosine kinase Indicated for HIV (both -1 and -2), and Hepatitis B (a DNA retrovirus, Baltimore Class VII) Toxicity for uninfected cells How does 3TC inhibit Hepatitis B?
G-protein-coupled receptors on phagocytes link microbe recognition with increased efficiency of intracellular killing. The NBT (Nitro Blue Tetrazolium) test is used to diagnose the genetic disorder Chronic Granulomatous Disease (CGD). To perform this test, peripheral blood cells from the patient are stimulated with bacterial extracts, and then incubated with the NBT compound. Normal neutrophils turn blue in this test due to cleavage of the compound, while patient neutrophils remain uncolored, as shown in Figure below. Name a neutrophil receptor that is likely to be stimulated by the bacterial extract in this assay, and describe how this receptor regulates the activity of the enzyme that cleaves NBT.
Each immunoglobulin (Ig) domain is composed of a structure known as a ‘b-sandwich,’ which consists of two b sheets covalently linked by a disulfide bond. Only a subset of the ~110 amino acids in each domain are required to establish this overall structure, and it is these amino acids that are highly conserved when comparing Ig domains to each other. What might be the advantage of this structure for use as antibody variable domains?
1 of 16 Data from an experiment is shown in the figure below. In the experiment, murine cells were treated with a specific a ligand that activates receptor R. In some cases, the cells were exposed to one of two drugs (X or Y) as well as the ligand or were left untreated (UT). After 30 minutes of treatment, the cells were lysed with a detergent-based buffer to release the soluble membrane, cyosolic and nuclear proteins. Samples from each cell extract were run (in duplicate) by SDS-PAGE (SDS-polyacrylamide gel electrophoresis) in order to separate the proteins by molecular mass (size). The separated proteins were then transferred to a nitrocellulose membrane which was then probed with different antibodies in a western blotting procedure to detect specific phosphorylated proteins or total proteins. If present in the cell extract, these proteins appear as a dark band in the relevant western blot image within the figure. Drug X Drug Y UT Ligand Ligand Ligand Western blotting antibodies…
PDB code 7BSJ Questions Q1 - What is the name of the protein Q2 - What does the protein do? Q3 - What are the structural features of the protein? Q4 - What are two features of your protein’s structure that make it different OR similar to haemoglobin? Q5 - Based on the structural properties of your protein, how resistant (or sensitive) would your protein be to heat denaturation and why?
Certain naphthalene derivatives, such as the dansyl group, exhibit a weak yellow fluorescence when they are in a highly polar environment (such as water) and an intense blue fluorescence when they are in a markedly nonpolar environment (such as hexane). The binding of ´ -dansyl-lysine to specific antibody is accompanied by a marked increase in its fluorescence intensity and a shift in color from yellow to blue. What does this finding reveal about the hapten–antibody complex?
Experiments are performed to analyze protein tyrosine phosphorylation in response to TCR stimulation. For these experiments, T cells are stimulated with anti-CD3 antibody, and then lysates are prepared and run on a protein (SDS-PAGE) gel to separate the proteins by molecular weight. The proteins are transferred from the gel to a membrane for immunoblotting using an antibody that binds to all phosphorylated tyrosine residues in any protein; this antibody is called ‘anti-phospho-tyrosine antibody,’ and is abbreviated as anti-P-Y. The results are shown in the figure below. You confirm that the mutant T cells express normal levels of all the proteins detected in the WT cells, including PLC-g, SLP-76, ITK, ZAP-70, LCK, LAT, and the CD3 and TCRz proteins. Based on these data, which of the following proteins (biotin, hygromycin, and streptavidin) can rule out its presence? Briefly explain your answer. What protein is most likely defective in the mutant cells and why? For the protein you…
Classify the symmetrical arrangement ofthe subunits (e.g., C2 , C3 , D 2 , helical, icosahedral). 1. Proteobacterial nitrite sensor (3PNS):2. Pseudomonad oligosaccharide receptor (7POR):3. Adenoviral structural protein (8ASP)
Certain antibodies have been shown to bind only to the folded structure oftheir target protein ligand; yet others will bind to both the folded and denatured states of the same protein ligand. Explain this observation.