Which of the following statements about GTP and GTPases is correct? 1. GTPase activating protein (GAP) binds to GTPase when it is in the active state. 2. The exchange factor GEF binds GTP directly and delivers it to the GTPase. 3. The "switching" behaviour of GTPase is because GTP hydrolysis causes the enzyme to change shape. 4. Structural differences in the terminal phosphate group explains why ATP hydrolysis releases

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Many cellular processes require the hydrolysis of GTP to GDP. However, unlike ATP, GTP
hydrolysis is often not used as an energy source for the cell, but rather, is associated with a
group of enzymes called GTPases.
Which of the following statements about GTP and GTPases is correct?
1. GTPase activating protein (GAP) binds to GTPase when it is in the active state.
2. The exchange factor GEF binds GTP directly and delivers it to the GTPase.
3. The "switching" behaviour of GTPase is because GTP hydrolysis causes the enzyme to
change shape.
4. Structural differences in the terminal phosphate group explains why ATP hydrolysis releases
energy and GTP does not.
O 1,2 and 3
O 1 and 3
O 2 and 4
O 4 only
O All of 1,2.3 and 4 are correct
Transcribed Image Text:Many cellular processes require the hydrolysis of GTP to GDP. However, unlike ATP, GTP hydrolysis is often not used as an energy source for the cell, but rather, is associated with a group of enzymes called GTPases. Which of the following statements about GTP and GTPases is correct? 1. GTPase activating protein (GAP) binds to GTPase when it is in the active state. 2. The exchange factor GEF binds GTP directly and delivers it to the GTPase. 3. The "switching" behaviour of GTPase is because GTP hydrolysis causes the enzyme to change shape. 4. Structural differences in the terminal phosphate group explains why ATP hydrolysis releases energy and GTP does not. O 1,2 and 3 O 1 and 3 O 2 and 4 O 4 only O All of 1,2.3 and 4 are correct
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