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WHICH OF THE FOLLOWING STATEMENTS IS CONSISTENT WITH THE RESULTS OF THE EXPERIMENT? Normal prostate epithelium and tumor-derived prostate epithelium produce ATP at equal rates. Tumor-derived prostate epithelium produces ATP at a slower rate than normal prostate epithelium. Normal prostate epithelium produces ATP at a faster rate than tumor-derived prostate epithelium. Tumor-derived prostate epithelium produces ATP at a faster rate than normal prostate epithelium.

WHICH OF THE FOLLOWING STATEMENTS IS CONSISTENT WITH THE RESULTS OF THE EXPERIMENT? Normal prostate epithelium and tumor-derived prostate epithelium produce ATP at equal rates. Tumor-derived prostate epithelium produces ATP at a slower rate than normal prostate epithelium. Normal prostate epithelium produces ATP at a faster rate than tumor-derived prostate epithelium. Tumor-derived prostate epithelium produces ATP at a faster rate than normal prostate epithelium.

Human Physiology: From Cells to Systems (MindTap Course List)
Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter2: Cell Physiology
Section: Chapter Questions
Problem 10RE: Using the answer code on the right, indicate which form of energy production is being described: 1....
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WHICH OF THE FOLLOWING STATEMENTS IS CONSISTENT WITH THE RESULTS OF THE EXPERIMENT?

        
Normal prostate epithelium and tumor-derived prostate epithelium produce ATP at equal rates.

        
Tumor-derived prostate epithelium produces ATP at a slower rate than normal prostate epithelium.

        
Normal prostate epithelium produces ATP at a faster rate than tumor-derived prostate epithelium.

        
Tumor-derived prostate epithelium produces ATP at a faster rate than normal prostate epithelium.

Scientific evidence suggests that tumor cells, because they divide more rapidly than nontumor cells, have increased energetic requirements. Investigators are curious about how the cellular metabolic processes of cancer cells may be altered to meet these greater energetic demands. In eukaryotic cells, the complete oxidation of glucose involves three processes: glycolysis in the cytosol, and the Krebs cycle and electron transport in the mitochondria. The vast majority of the useful cellular energy that is extracted from a glucose molecule (in the form of ATP) is generated by the mitochondrial electron transport chain. Researchers are interested in determining whether cancer cells rely more heavily on glycolysis alone or on glycolysis and electron transport for their cellular energy. A reliance on one process instead of another might suggest targeting that process as a potential therapy. Normal prostate epithelial cells and tumor-derived prostate cells were cultured in normal media (control), or media supplemented with the glycolytic inhibitor iodoacetate (IAA) or Piericidin A. lodoacetate directly prevents the formation 1,3-bisphosphoglycerate, while Piericidin A inhibits complex I of the mitochondrial electron transport chain. Cellular production of ATP was measured and the results are given in the figure that follows. tumor-derived prostate epithelium normal prostate epithelium Moles of ATP produced per minute 35 30 25 20 15 10 сл 0 control w/IAA w/Piericidin A
Transcribed Image Text:Scientific evidence suggests that tumor cells, because they divide more rapidly than nontumor cells, have increased energetic requirements. Investigators are curious about how the cellular metabolic processes of cancer cells may be altered to meet these greater energetic demands. In eukaryotic cells, the complete oxidation of glucose involves three processes: glycolysis in the cytosol, and the Krebs cycle and electron transport in the mitochondria. The vast majority of the useful cellular energy that is extracted from a glucose molecule (in the form of ATP) is generated by the mitochondrial electron transport chain. Researchers are interested in determining whether cancer cells rely more heavily on glycolysis alone or on glycolysis and electron transport for their cellular energy. A reliance on one process instead of another might suggest targeting that process as a potential therapy. Normal prostate epithelial cells and tumor-derived prostate cells were cultured in normal media (control), or media supplemented with the glycolytic inhibitor iodoacetate (IAA) or Piericidin A. lodoacetate directly prevents the formation 1,3-bisphosphoglycerate, while Piericidin A inhibits complex I of the mitochondrial electron transport chain. Cellular production of ATP was measured and the results are given in the figure that follows. tumor-derived prostate epithelium normal prostate epithelium Moles of ATP produced per minute 35 30 25 20 15 10 сл 0 control w/IAA w/Piericidin A
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