Which of the listed effects would be brought about by any enzyme catalyzing the following reaction? k1 S P where Keg = [P]/[S] and AG°' = -RT In K'eg k2 (a) Decreased Kegi (b) increased kı; (c) increased K'eg; (d) increased AG*; (e) decreased AG*; (f) more negative AG°´; (g) increased k2. Justify your answer using a reaction energy diagram.
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
![Which of the listed effects would be brought about by any enzyme catalyzing the following reaction?
k1
S
P
where K'eg = [P]/[S] and AG°' = -RT In K'ea
k2
(a) Decreased K'egi (b) increased k1; (c) increased K'ea; (d) increased AG*; (e) decreased AG*; (f) more
negative AG°; (g) increased k2. Justify your answer using a reaction energy diagram.
Problem 2.
(a) The following data were obtained for an enzymatic reaction, in which the total enzyme concentration
was 0.005 mM. Without plotting the data, can you estimate the approximate Km for this enzymatic
reaction? How did you determine it?](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff5df66e8-4c10-492e-b5b2-868005db19b6%2F4ce4a99a-9360-4dfe-8db2-e2cab31f4486%2Fw81xyub_processed.png&w=3840&q=75)
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