Which scientist suggested that enzymes bind the transition states of their catalyzed reactions better than their substrates?     Pauling     Michaelis     Fisher     Richardson

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Chapter1: Biochemistry: An Evolving Science
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  1. Which scientist suggested that enzymes bind the transition states of their catalyzed reactions better than their substrates?

       

    Pauling

       

    Michaelis

       

    Fisher

       

    Richardson

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Transition state is a condition of molecular structure in which a molecule is neither a substrate nor a product. To generate a product from substrate molecule, all chemical reaction must pass through the transition state. 

The maximum energy along the reaction coordinate corresponds to the transition state.

The ability of the enzyme to speed up the reaction is dependent on its ability to stabilise the transition state. 

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