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- 4. Which of the following molecules will rotate the plane of polarization of plane-polarized light? 1.04 = || = Holla HO OH IV a VDraw the 4 skeletal structures of all isomers of C₆H₁₂ that have the (E)-configuration.Cymbalta (shown below) is an antidepressant. How many asymmetric centers are present in this structure? SIN N.