why The chromatids formedby recombination within the inversion loop of a paracentric inversionheterozygote   containtwo centromeres or none, instead of the normal one ?

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter6: Cytogenetics: Karyotypes And Chromosome Aberrations
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Problem 3QP: A colleague e-mails you saying that she has identified an interesting chromosome variation at 21q13....
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 why The chromatids formed
by recombination within the inversion loop of a paracentric inversion
heterozygote   contain
two centromeres or none, instead of the normal one ?

Expert Solution
Step 1

When the region between two breaks of the same chromosome rotate 180°, it results in chromosomal aberration called inversion. When the inversion occurs between the arms of the same chromosome, it is called paracentric but when inversion involves the centromere along with arms it is called pericentric.

Step 2

If we look at the mechanism of the suppression in an inversion of heterozygotes with a paracentric inversion. The crossover within the inversion loop Is given below. The 2 non-sister chromatids which are not allowed in crossover ultimately ends up in the normal gametes that carry either the wild-type or the inverted chromosome.  The products of the crossover are an acentric chromatid and a dicentric instead of being a simple allele’s recombination.

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