You apply a drug to neurons that blocks the KCC transporter. As a result, you have a rise in intracellular CI- levels and a shift in the Cl- equilibrium potential. Currents generated by which of the following ion channels would be altered as a result of this drug. NMDA GABA NACHR ASIC All of the above

You apply a drug to neurons that blocks the KCC transporter. As a result, you have a rise in intracellular CI- levels and a shift in the Cl- equilibrium potential. Currents generated by which of the following ion channels would be altered as a result of this drug. NMDA GABA NACHR ASIC All of the above

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter4: Principles Of Neural And Hormonal Communication

Section: Chapter Questions

Problem 17RE

See similar textbooks

Similar questions

A local anesthetic (Na+ channel blocker) should do which of the following Make the resting membrane potential more negative Decrease the after hyperpolarization Block the rising phase of the AP None of these
Ion channels can open or close based on electrochemcical gradient. True False
Grasshopper mouse lives in the desert of Arizona where there are scorpions whosevenoms are toxic by activating neuronal Nav channels or impair channel inactivation,thereby increasing neuron excitability causing pain/or paralysis. Interestingly, thegrasshopper mouse (Onychomys torridus) kills and consumes bark scorpions whileshowing little signs of discomfort when stung by the scorpion. On the other hand regularmouse is affected severely by the scorpion stung. What could be the molecular reason forthat adaptation
Epilepsy is a chronic disorder characterized by seizures that result whenneurons in the brain produce excessive action potentials. Channelopathiesare genetic disorders caused by mutations in ion channel genes, whichresult in ion channels that do not function normally. What kind of Na+ orCa2+channelopathies might contribute to epilepsy?
Describe the action potential in terms of the different functional states of the voltage- gated Na+ membrane channels (Note: there are three states)
When Tetrodotoxin is administered in bathing medium of a nerve fibre during voltage clamp experiments the membrane current may show which one of the following changes? Absence of inward membrane current Higher amplitude of inward membrane current Absence of outward membrane current O Higher amplitude of outward membrane current
Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)
The rate at which the Na+K+ pump operates is not constant but is controlled by a combined effect of changes in ICF Na+ concentration and ECF K+ concentration. Do you think the changes in both ICF Na+ and ECF K+ concentration following a series of action potentials in a neuron would accelerate, slow down, or have no effect on the Na+K+ pumps in this cell?
An 82-year-old woman is brought to the emergency room complain- ing of nausea, vomiting, muscle cramps, and generalized weakness. Labo- ratory analysis reveals significant hyperkalemia. Elevations of extracellular potassium ion concentration will have which of the following effects on nerve membranes? a. The membrane potential will become more negative b. The sodium conductance will increase c. The potassium conductance will increase d. The membrane will become more excitable e. The Na*-K* pump will become inactivated
High Potassium can cause the symptoms seen in hyperkalemia. What about low potassium, known as hypokalemia? What affectwould hypokalemia have on the resting membrane potential and action potentials?
The traces below show the action potential waveforms in an external meidum of different concentrations of * 40 100% 50% 33% 40 1 2 time (msec) calcium chloride potassium O sodium
The endogenous ligand for an ion channel causes the influx of 50 Na+ ions per second. This ion channel has constitutive activity of 10 Na+ ions per second. If drug A binds to the ion channel and causes the influx of 50 Na+ ions per second, which of the following categories best describes drug A? Group of answer choices full agonist antagonist partial agonist inverse agonist