You are evaluating a trait that is associated with fur color in mice. The trait is controlled by a single autosomal gene where A1 codes for dark fur and A2 codes for light fur. You are mating two homozygous parents- a male that is A1A1 and a female that is A2A2. You learn that the trait is involved in genomic imprinting where the paternally inherited allele is heavily methylated to the point where it is completely silenced. If you performed a RECIPROCAL CROSS what phenotypic ration would you predict among the progeny? 100% Dark 100% Light 3Dark:1Light 1Light:3 Dark None of the answers I want are shown.

You are evaluating a trait that is associated with fur color in mice. The trait is controlled by a single autosomal gene where A1 codes for dark fur and A2 codes for light fur. You are mating two homozygous parents- a male that is A1A1 and a female that is A2A2. You learn that the trait is involved in genomic imprinting where the paternally inherited allele is heavily methylated to the point where it is completely silenced. If you performed a RECIPROCAL CROSS what phenotypic ration would you predict among the progeny? 100% Dark 100% Light 3Dark:1Light 1Light:3 Dark None of the answers I want are shown.

Name: You are evaluating a trait that is associated with fur color in mice.
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Description: You are evaluating a trait that is associated with fur color in mice. The trait iscontrolled by a single autosomal gene where A1 codes for dark fur and A2 codes forlight fur. You are mating two homozygous parents- a male that is A1A1 and a femaletha

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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Bloom syndrome is an autosomal recessive disease that exhibitshaploinsufficiency. A recent survey showed that people heterozygousfor mutations at the BLM locus are at increased risk of colon cancer.Suppose you are a genetic counselor. A young woman is referred to youwhose mother has Bloom syndrome; the young woman’s father has nofamily history of Bloom syndrome. The young woman asks whether sheis likely to experience any other health problems associated with herfamily history of Bloom syndrome. What advice would you give her?
Here is a family pedigree for an imprinting disorder caused by a loss of function mutation in a single imprinted gene. After generation I only related individuals are shown. You can assume that the parents not included in the pedigree did not carry the mutation. %3D II IV V Male O Female Affected Carrier a) Does the mutation involve a gene that is normally expressed from the maternal or from the paternal allele? Briefly explain your logic. b) Identify two ways in which the pattern of inheritance shown in the pedigree is different from X-linked inheritance I. Parthenogenesis has been documented in most vertebrate Classes (e.g. birds, fish) but never in mammals. Genomic imprinting provides one explanation for this observation. Why?
You believe that the gene you're investigating, eyes absent, is an autosomal recessive mutant allele F7 ge in Drosophila. You set up a cross between a true-breeding mutant male and a true-breeding wildtype female to obtain the F1 generation. You then cross the F1 flies. In the F2 offspring, you observe the following: 237 wild-type males 180 wild-type females 70 mutant males 83 mutant females Based on these findings, is the mutant allele autosomal recessive? How do you know?
Examine the two pedigrees shown in Figure Q7–3.One results from deletion of a maternally imprinted auto-somal gene. The other pedigree results from deletion of apaternally imprinted autosomal gene. In both pedigrees,affected individuals (red symbols) are heterozygous forthe deletion. These individuals are affected because onecopy of the chromosome carries an imprinted, inactivegene, while the other carries a deletion of the gene. Dottedyellow symbols indicate individuals that carry the deletedlocus, but do not display the mutant phenotype. Whichpedigree is based on paternal imprinting and which onmaternal imprinting? Explain your answer.
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In 1995, doctors reported a Chinese family in whichretinitis pigmentosa (progressive degeneration of theretina leading to blindness) affected only males. Allsix sons of affected males were affected, but all of thefive daughters of affected males (and all of thechildren of these daughters) were unaffected.a. What is the likelihood that this form of retinitispigmentosa is due to an autosomal mutationshowing complete dominance?b. What other possibilities could explain the inheritance of retinitis pigmentosa in this family? Whichof these possibilities do you think is most likely?
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There are two genetic disorders that result from mutation in imprinted genes: Prader-Willi syndrome, Angelman syndrome. Angelman syndrome results from deletion of UBE3A, which is a gene imprinted such that only the maternal copy is expressed. In the pedigree above, individual I-1 is heterozygous for a deletion of UBE3A and does not have Angelman syndrome. Individual I-2 is homozygous wild type for UBE3A. Which individuals in the pedigree are at risk for exhibiting Angelman syndrome, if any? (Who could potentially have the syndrome, based on what alleles it is possible for them to inherit and express?) Question 8 options: Only I-1 could have been at risk. If he does not have the syndrome, no one in the pedigree could. Only III-1 is at risk I-1, II-2, and III-1 are all at risk Only II-2 is at risk No one in the pedigree is at risk Both II-2 and III-1 are at…
In Drosophila, a cross (cross 1) was made between twomutant flies, one homozygous for the recessive mutationbent wing (b) and the other homozygous for the recessivemutation eyeless (e). The mutations e and b are alleles oftwo different genes that are known to be very closelylinked on the tiny autosomal chromosome 4. All the progeny had a wild-type phenotype. One of the female progeny was crossed with a male of genotype b e/b e ; we willcall this cross 2. Most of the progeny of cross 2 were of theexpected types, but there was also one rare female ofwild-type phenotype.a. Explain what the common progeny are expected tobe from cross 2.b. Could the rare wild-type female have arisen by (1)crossing over or (2) nondisjunction? Explain.
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