Ligand

• INTRODUCTION: The metal chelates of various ligands play pivotal role in many important medicinal applications. They also useful for metal extraction and detection. The present aspect is context to the novel heterocyclic ligand containing .pharmaceutica active segments like benzofuran, 1,3,4-oxadiazoe and p-amino salicylic acid as ligand. So the literbture review is as follow: • LITERATURE REVIEW: Chelating agents, because of their metal specificity or selectivity, can function as good flotaids

between endothelin receptor populations on the ventricular cardiomyocyte membrane of spontaneous hypertensive rats at 16 weeks old. The use of radioligand competitive binding assay method, involving the displacement of [125I]ET-1 by 3 competitive, cold ligands, ET-1, ET-3 and BQ123, allowed for the generation of competition binding curves, that adopted either a one-site or two-site model and allowed the determination of relative IC50s and identification of receptor proportions. ET-3 produced a two site

second, the understanding of what coordination is, and the way it's to be distinguished from alternative, non-symmetrical relations (e.g. subordination). The major breakthrough occurred once Alfred Werner put forward in 1893 that Co(III) bears six ligands in an octahedral geometry. His theory permits one to grasp the distinction between coordinated and ionic in a compound, for instance chloride within the cobalt ammine chlorides and to clarify several of the earlier unexplainable isomers. In 1914,

derivatives as potent inhibitors of glycosylceramide synthase. In this approach the experimental dataset was divided into training and test sets and the model was chosen based on randomized trial distribution which has high correlation factors. A ligand-based pharmacophore and atom-based 3D-QSAR studies were carried out on a set of 65 inhibitors of GCS. After the QSAR studies, a five-point pharmacophore with two hydrogen bond acceptors (A), two hydrophobic group (H) and one ring aromaticity (R) was

CHAPTER 1 INTRODUCTION 1.1 Background and Problem Statement 1.1.1 Schiff Base The condensation product of primary amines with active carbonyl compounds have resulted in the formation of Schiff base compound. This has been reported by Hugo Schiff in 1864. Schiff base compound contain azomethine -C≡N with a general formula RHC=N-R’ where R and R’ are alkyl, aryl, cyclo alkyl or heterocyclic groups which may be variously substituted. These compounds are also known as anils, imines or azomethines

COMPLEXOMETRIC DETERMINATION OF WATER HARDNESS DR. BUDRUK CHM 152 LL SEAN MARKIS 4 FEBRUARY 2015 Introduction Using a Lewis base neutral molecule to donate electron pairs (ligands) to a Lewis acid metal ion center to form a single cluster (complex) ion. When the complex ions forms with a metal ion (chelation) the ligand used is called the (chelating agent). EDTA acts as a great chelating agent due to the Nitrogen and Oxygen donating an electron pair to the metal ion center to form an octahedral

Matriculation Number: A0111185R Date of Experiment: 17 February 2015 Experiment 6: Synthesis, Electronic Spectra, Structural Isomerism: Octahedral Co(III) complexes with Chloride and Ethylenediamine Ligands Abstract: In this experiment, Δ/Λ-[Co(en)3]Cl3∙4H2O was synthesized and the absorbance in UV-vis spectrum was recorded. Δ/Λ-[Co(en)3]Cl3∙4H2O has an εmax of 197.33 mol–1dm3cm at 466.00nm and 210.39mol–1dm3cm-1 at 338.00nm. and the colour of the crystals

indicate the endpoint of the reaction. Theories and Concepts: The anion of the acid, EDTA4-, will complex to the metal. This anion reacts with the metal by forming coordinate-covalent bonds with the metal. This is a coordination compound. This ligand is called a chelate because it can form coordinate-covalent bonds

between proteins or between proteins and ligands. In 1962, Max Perutz and John Kendrew received Nobel award for the work on structure of myoglobin. Since then, several Scientists have made considerable contribution for the determination of protein

the nitro and nitrito group. Yield for nitritopentamminecobalt(III) Chloride was obtained to be = 1.9221 g(73.24 %) and yield for nitropentamminecobalt(III) Chloride = 0.76 g(76 %) Introduction Linkage isomers may arise when one or more of the ligands can coordinate to the metal ion in more than one way. The first reported example of linkage