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Essay on West Nile Virus

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West Nile Virus has emerged in recent years throughout the temporate zones of Europe and North America. Causing a variety of conditions in its hosts, the most serious manifestation of WN virus infection is fatal encephalitis (inflammation of the brain) in humans and horses, and many birds.

History
While many forms of encephalitis exist, West Nile Virus was first isolated and identified in the West Nile District of Uganda in 1937. The virus, which was seemingly isolated to North Eastern Africa, became recognized as a cause of severe human meningoencephalitis (inflammation of the spinal cord and brain) in elderly patients during an outbreak in Israel in 1957. In addition to the human victims of this disease, the virus was found Egypt and …show more content…

* Family: Flaviviridae * Genus: Flavivirus Japanese Encephalitis Antigenic Complex * Complex includes: Alfuy, Cacipacore, Japanese encephalitis, Koutango, Kunjin, Murray Valley encephalitis, St. Louis encephalitis, Rocio, Stratford, Usutu, West Nile, and Yaounde viruses. * Flaviviruses: share a common size (40-60nm), symmetry (enveloped, icosahedral nucleocapsid), nucleic acid (positive-sense, single stranded RNA approximately 10,000-11,000 bases), and appearance in the electron microscope. Therefore, images of West Nile virus are representative for this group of viruses.

Transmission Cycle
West Nile Virus is known as an arthropod-born virus, or an arbovirus, and are transmitted and sustained within blood feeding arthropods, such as the mosquito. The disease, while having no apparent effect on the host, is then transmitted as the mosquito takes a blood meal. As the source of infection, the mosquito or other blood feeding arthropod is known as a primary vector. However, because the life cycle of the mosquito is reletively short an additional host is needed to maintain the life cycle of the virus.

The second part of this life cycle involves a non-human, vertebrate host. Frequently these cycles occur undetected until the virus escapes this cycle and infects a species that does not have an immunity to the pathogen. In the case of West Nile, birds often act as the reservoir vertebrate host. Although brids, particularity crows

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