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- 7. What are the determinants for drug liposolubility?1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…40. What are xenobiotic? Give the factors affecting on drug metabolism.
- 4. A physician orders Humulin R 35 units qam and q5pm and Humulin N 60 units qam. a) How many 10-mL vials of Humulin R U-100 insulin are needed for a one month supply? b) How many 10-mL vials of Humulin N U-100 insulin are needed for a one month supply?3.What is the meaning of the term ergogenic aid? What is an ergolytic effect?(a) Explain how polymorphism contributes to different drug metabolism among individuals. (b) What are the potential consequences of a poor metabolizer?
- Summarize the mechanism of action and the therapeutic use of the following antifungal drugs: miconazole, nystatin, griseofulvin, amphotericin B, and 5-flucytosine.1. What is the drug target?Explain three functionally distinct compartments in drug absorption 1.intracellular compartment 2.plasma compartment 3.interstitial compartment
- 27. Which of the following is an invasive procedure in antiaging treatment.... A. use of sunscreenB. use of antioxidantsC hormone therapyD. radiofrequency 29. The following are indicators of the stability of a product, except..... A. change in pHB. dosage form does not changeC) the growth of microorganismsD. increased side effectGive the mechanism of action, contraindications and structure of 1. ASA 2. Ibuprofen 3. Diclofenac 4. Mefenamic acid 5. Indomethacin27. Why should ciprofloxacin use be limited in pregnant women and children? Group of answer choices it causes softness of teeth it is associated with vasodilation and anaphylactic shock it affects cartilage development it disrupts normal flora; induces pseudomembranous colitis it induces aplastic anemia it's toxic to kidneys 28. Vancomycin, a narrow spectrum antibiotic that targets bacterial cell wall. What's the mechanism of action ? Group of answer choices prevents cross bridging ; binds to amino acid of the tetrapeptide chain breaks down beta lactam ring inhibits precursors transport across the membrane binds to PBP and prevents cross bridging interferes with ala-ala bridge in Gram (+)ve bacteria inhibits mycolic acid synthesis