4. The anisole derivative below undergoes a selective cross coupling reaction on only one of the two bromides. Predict the structure of the product and explain why that is the mechanistically preferred product. OMe Pd°Ln, PhB(OH), (1 equiv) biaryl product Br K,PO,. THFM,0, 80 °c Br
4. The anisole derivative below undergoes a selective cross coupling reaction on only one of the two bromides. Predict the structure of the product and explain why that is the mechanistically preferred product. OMe Pd°Ln, PhB(OH), (1 equiv) biaryl product Br K,PO,. THFM,0, 80 °c Br
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter24: Catalytic Carbon-carbon Bond Formation
Section: Chapter Questions
Problem 24.22P
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![4. The anisole derivative below undergoes a selective cross coupling reaction on only one of the two bromides. Predict the
structure of the product and explain why that is the mechanistically preferred product.
OMe
Pd°Ln, PhB(OH), (1 equiv)
biaryl product
Br
K,PO,. THFM,0, 80 °c
Br
5. A reaction proceeds with a 13:3 ratio of enantiomers. Convert this ratio to the percent enantiomeric excess (%ee).](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F236af608-9c27-44dd-8b5b-367f5f8432be%2F987bd2e8-6151-40f9-911b-2a15e3d9342f%2F7ziv58a.bmp&w=3840&q=75)
Transcribed Image Text:4. The anisole derivative below undergoes a selective cross coupling reaction on only one of the two bromides. Predict the
structure of the product and explain why that is the mechanistically preferred product.
OMe
Pd°Ln, PhB(OH), (1 equiv)
biaryl product
Br
K,PO,. THFM,0, 80 °c
Br
5. A reaction proceeds with a 13:3 ratio of enantiomers. Convert this ratio to the percent enantiomeric excess (%ee).
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