ANSWER THE FOLLOWING PROBLEM, ILLUSTRATE YOUR WORK AND EXPLAIN YOUR ANSWER FOR BETTER UNDERSTANDING. 8. A peptide has the abbreviation 'GREAT'. Draw the peptide and give its systematic name
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- Given below are sequences of amino acids present in an oligo-peptide chain. Count the overall charge of each assigned peptide and write it in your answer. Along with it also mention that toward which electrode (cathode or anode) will the peptide move? Please remember that cathode is a negativeelectrode and anode is a positive electrode. Ile-Lys-Arg-Trp-Lys-Asn-Glu-His-Pro-Asp-Ala-Tyr-Phe-Glu-Met-Phe-Gly-ValLook at the structure shown below and answer the following questions: NH, NH, NH HO NH NH, Download image.. a. The structure shown on the scheme is (select from: oxytocin, arginine vasopressin ) b. Name on the N-terminal amino acid residue: c. Name on the C-terminal amino acid:Given below are sequences of amino acids present in an oligo-peptide chain. Count the overall chargeof each assigned peptide and write it in your answer. Along with it also mention that toward swhichelectrode (cathode or anode) will the peptide move? Please remember that cathode is a negativeelectrode and anode is a positive electrode. Ile-Lys-Arg-Trp-Lys-Asn-Glu-His-Pro-Asp-Ala-Tyr-Phe-Glu-Met-Phe-Gly-Val
- (a) Answer all sections (i)- (Iv). Below is given the structure of three anti-HIV drugs: OH Meo. OMe NH Ph Nevirapine Atazanavir Staudivine (i) Give the drug target and discuss the anti-HIV mechanism of each of these drugs. Vaccines are an attractive prophylactic treatment against both viral and bacterial diseases. A number of glycaconjugate vaccines using bacterial polysaccharide structures conjugated to protein carriers have been introduced into mass vaccination schemes with excellent results. What differences are there in the immune response to a glycoconjugate vaccine as compared to a polysaccharide vaccine? These glycoconjugate va nes has been used for 30 years without any change in their structures, while the composition of the flu vaccine, based on attenuated or killed virus particies, is changed from year to year. Discuss the reason behind this. (iv) Discuss why it has not been possible to develop a (part structure) vaccine against the HIV virus, based on either I) viral…You are analyzing the peptide ala-ile-glu-lys-phe-val- tyr-cys. If you treat the peptide with chymotrypsin, which technique would be best to separate the fragments? O a. ultracentrifugation O b. affinity chromatography O c. dialysis d. gel filtration chromatography O e. ion exchange chromatography What is an advantage of NMR spectroscopy over x-ray crystallography in studying protein structure?draw a “trans” and a “cis” peptide bond of alanine and threonine with the peptide bond lying in the plane of the paper. Draw a second view of each peptide bonds now looking down/along the peptide bond (i.e. one atom of the peptide bond will be in front and will obscure the second one behind it). Using a circular arrow, demonstrate how the torsion angle can be directly “read” from the picture. You can do this with an accuracy of ~10°. Provide an explanatory caption.
- complete the sentence In the Sanger method, the nitrogen from the tripeptide (give the name of the tri-peptide using the one-letter-codes of the 3 amino acids forming it, no spaces or punctuation between letters. eg. ABC) (. ) shown above acts as a ( )Provide a detailed plan and explanation on how to synthesize the following peptide by using Fmoc- based solid phase synthesis: H-Leu-Ala-His-Tyr-Asn-Lys-NH2 The written report should include a description of the choice of resin, linker, protecting groups, coupling reagents, amino acid 'building blocks', etc. needed in order to conduct this synthesis.A NONAPEPTIDE that attacks and kills cancer cells has just been recently isolated from a rare fungus. Amino acid analysis of the peptide reveals the following information below: (NOTE: when the sequence is not known, a comma separates the amino acids) Hytrezine Acid tydrolysis (6 N HC) at 110C Nonapeptide (2) Arg. Gin, (2) Tyr, Gly, Ser, Thr, and Met 24-dinitrofieorebenzene DNP-Thr Gin and modified free Peptide 1 (Arg. Thr, Ser) amino acids Cleavoge with Trypsin, then chrametogruphy Peptide 2 (Gly. Tyr, Arg) Met Tripeptide (yanopen bromide Dipeptide Cleovege with Chymetrypsin, then chromatograophy Peptide 3 (Arg, Ser, Tyr, Thr) Amino acid Peptide 4 (Gly, Arg. Tyr)
- In the given structure below, 1. What protein was used as the template for modelling the structure of the assigned amino acid sequence? 2. How many alpha-helices and beta-sheets are there?E. PROTEIN PRIMARY STRUCTURE ELUCIDATION. 1. Determine the primary structure of the protein described below. Write the final sequence using the corresponding three-letter code for each amino acid. Example: M-F-Y-R should be written as Met-Phe-Tyr-Arg Treatment with cyanogen bromide and sequencing yields the following peptide fragments: o D-M o R-A-Y-G-N o L-F-M Chymotrypsin digestion and sequencing yields the following peptide fragments: o G-N D-M-L-F o M-R-A-Y o oPlease propose a method to synthesize the following peptide. Leu.Gly.Ala (automated synthesis only)