Choose (+) if the following circumstances or situations will most likely result to production of intrinsic activity, if otherwise, choose (-). Dissociation of drug molecule from binding site
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Choose (+) if the following circumstances or situations will most likely result to production of intrinsic activity; if otherwise, choose (-)
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- What are the similarities and differences (*in terms of structure) between this analgesic and aspirin? What are the major advantage of this analgesic? Structure of analgesic is provided, please draw structure of aspirin too.1 of 16 Data from an experiment is shown in the figure below. In the experiment, murine cells were treated with a specific a ligand that activates receptor R. In some cases, the cells were exposed to one of two drugs (X or Y) as well as the ligand or were left untreated (UT). After 30 minutes of treatment, the cells were lysed with a detergent-based buffer to release the soluble membrane, cyosolic and nuclear proteins. Samples from each cell extract were run (in duplicate) by SDS-PAGE (SDS-polyacrylamide gel electrophoresis) in order to separate the proteins by molecular mass (size). The separated proteins were then transferred to a nitrocellulose membrane which was then probed with different antibodies in a western blotting procedure to detect specific phosphorylated proteins or total proteins. If present in the cell extract, these proteins appear as a dark band in the relevant western blot image within the figure. Drug X Drug Y UT Ligand Ligand Ligand Western blotting antibodies…How does ligand binding, and voltage changes regulate specific types of ion channels? Provide examples of different drugs action on such targets by giving discussing briefly their mechanism of action.