Consider the following two nonhomologous wildtype chromosomes, where letters or numbers represent genes, the "-" represents the centromere of each chromosome, and chromosomes are shown on separate lines. ABCDE-FGHIJK 123-45678 Identify the type of rearrangement shown in each of the following (A-C) and then identify whether it is balanced or unbalanced. Assume that the individual is diploid and heterozygous for the rearrangement. A. ABCDE-FGHIJKGH 123-45678 Rearrangement: [Select] • Balanced or Unbalanced: [Select] B. ABCDGF-EHIJK 123-45678 Rearrangement: [Select] Balanced or Unbalanced: [Select]
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- Variations in Chromosome NumberAneuploidy Describe the process of nondisjunction and explain when it takes place during cell division.Rice has a chromosome number of 2n = 24. If different aneuploids are available in rice, identifythe specific aneuploidy that shows the following chromosomal configurations at diakinesis ormetaphase I. Also provide the formula and chromosome number of the different aneuploids. Complete the table. Chromosome configuration at diakinesis or metaphase I Specific Type of Aneuploidy Formula (e.g. 2n+1) Chromosome number (2n=24) Types of gametes n, n+1, n+2, n-1, n-2) a. 1 III + 11 II b. 1 IV + 11 II c. 1 I + 11 II d. 11 II e. 2 I + 10 IIHere is a depiction of the position of several genes on 2 chromosomes, with a dash "-" depicting the position of the centromere. Chromosome A has genes ABCD-EFGHIJ Chromosome B has genes 1234-56789. Please name the kind of rearrangement that would result in the following derivative chromosomes: 12D-EFGHIJ AB4-56789 O Unbalanced reciprocal translocation Unbalanced nonreciprocal translocation Balanced reciprocal translocation Balanced nonreciprocal translocation
- Assume that the diploid number of a certain species is four chromosomes, two large and two small (2n=4). a) Of the following figures, which represents a 3n (triploid) cell in mitotic metaphase? b) For each of the wrong answers from part (a) above, explain briefly why it cannot represent a triploid cell in mitotic metaphase.A diploid individual is heterozygous for a chromosome rearrangement. The original chromosome and its rearranged homolog have the following segments, where ∙ represents a centromere: A B ∙ C D E F G A B ∙ C F E D G While paired in prophase I, a single crossing-over occurs between segment E and segment D of the paired chromosomes. Describe the unusual crossing-over structure that forms as a result.What gamete types will result from crossing over when meiosis is complete? please asapThe STR DNA marker DS11 is located on the p arm of the chromosome #8 in humans. Molecular analysis has shown that Charlie Chaplin is a heterozygote for the STR marker (genotype DS11A and DS11B) Using this knowledge, provide a diagram of meiosis showing only the movements of chromosome 8 (assume no nondisjunction). Throughout, indicate where the marker may be found (in other words, label the chromosome to show where the STR markers can be found. (Show ONLY the chromosomes at interphase, metaphase 1, end of meiosis 1, metaphase 2, and end of meiosis 2). Suppose Charlie conceived a son with a chromosome 8 trisomy. Molecular analysis of the STR DS11 marker revealed that his son carried two copies of the DS11A marker and a DS11C marker. Based on the data, determine if the nondisjunction occurred in Charlie or in the mother? Provide your reasoning.
- A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?A diploid species has 3 pairs of chromosomes in its somatic cells. In males, the first pair is large submetacentric[1]; the second is medium acrocentric[2], and the third is small telocentric[3]. In females, the first two pairs are like those of the males while the third is large metacentric[4][5], with satellite4 Illustrate the karyograms (drawing/picture of the chromosome) of the following: A triploid cell in females tetrasomic cell in males tetraploid cell in females [1] submetacentric --centrosome is just above the middle of the chromosome [2] acrocentric --centrosome is much higher location than submetacentric so that the “p” arm of the chromosome is much shorter than the q arm [3] telocentric --the centromere is at the end of the chromosome [4] metacentric --centrosome is in the middle of the chromosome; thus the “p-arm” and the “q-arm” or both arms of the chromosome are equal in length [5] satellite-a constriction in an arm of a chromosome, aside…On Neurospora chromosome 4, the leu3 gene is just to theleft of the centromere and always segregates at the firstdivision, whereas the cys2 gene is to the right of the centromere and shows a second-division segregation frequency of 16 percent. In a cross between a leu3 strain anda cys2 strain, calculate the predicted frequencies of thefollowing seven classes of linear tetrads where l = leu3 andc = cys2. (Ignore double and other multiple crossovers.)
- In Neurospora, his2 mutants require the amino acidhistidine for growth, and lys4 mutants require theamino acid lysine. The two genes are on the samearm of the same chromosome, in the ordercentromere - his2 - lys4.A his2 mutant is mated with a lys4 mutant. Draw all ofthe possible ordered asci that could result from meioses in which the following events occurred, accountingfor the nutritional requirements for each ascospore.Ascospores without any copy of a chromosome willabort and die, turning white in the process.a. A single crossover between the centromere and his2b. A single crossover between his2 and lys4c. Nondisjunction during the first meiotic divisiond. Nondisjunction during the second meiotic divisione. A single crossover between the centromere andhis2, followed by nondisjunction during the firstmeiotic divisionf. A single crossover between his2 and lys4,followed by nondisjunction during the firstmeiotic divisionA woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown? (b) Using a drawing, demonstrate how these chromosomeswould pair during meiosis. Be sure to label the differentsegments of the chromosomes.(c) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement? The woman in above problem has had two miscarriages. Shehas come to you, an established genetic counselor, with thesequestions:(a) If not, what is the chance that she could have a normalchild? Provide an informed response to her concernsA woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown? (b) Using a drawing, demonstrate how these chromosomeswould pair during meiosis. Be sure to label the differentsegments of the chromosomes.(c) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement? The woman in above problem has had two miscarriages. Shehas come to you, an established genetic counselor, with thesequestions:(a) Is there a genetic explanation of her frequent miscarriages?