Terreic acid, shown below, is a naturally occurring antibiotic metabolite of the fungus Aspergillus terreus. Terreic acid hinders bacterial growth by covalently binding to (and thereby deactivating) the biosynthetic enzyme MurA, which is responsible for synthesizing the bacterial cell wall. In aqueous environments, terreic acid tautomerizes to a more stable enol form. Draw the two most stable enol tautomers of terric acid. Circle the tautomer above that you would expect to predominate inside a cellular environment.
Terreic acid, shown below, is a naturally occurring antibiotic metabolite of the fungus Aspergillus terreus. Terreic acid hinders bacterial growth by covalently binding to (and thereby deactivating) the biosynthetic enzyme MurA, which is responsible for synthesizing the bacterial cell wall. In aqueous environments, terreic acid tautomerizes to a more stable enol form. Draw the two most stable enol tautomers of terric acid. Circle the tautomer above that you would expect to predominate inside a cellular environment.
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter22: Reactions Of Benzene And Its Derivatives
Section: Chapter Questions
Problem 22.50P: Following is the structure of miconazole, the active antifungal agent in a number of...
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