tient was receiving an antibiotic as a constant rate infusion at an infusion rate of 22.01 mg/h. After six times the half life of this drug, the infusion was terminated and the plasma drug concentration was determined as 3.63 mg/L and 2.79 mg/L at 5.1 hours and 8.52 hours, respectively, following the termination of the infusion. The patient started displaying lung infection symptoms again and this antibiotic was to be administered via constant rate IV infusion again. Please calculate an IV loading dose that was used to achieve a steady state of 6.28 mg/L.
tient was receiving an antibiotic as a constant rate infusion at an infusion rate of 22.01 mg/h. After six times the half life of this drug, the infusion was terminated and the plasma drug concentration was determined as 3.63 mg/L and 2.79 mg/L at 5.1 hours and 8.52 hours, respectively, following the termination of the infusion. The patient started displaying lung infection symptoms again and this antibiotic was to be administered via constant rate IV infusion again. Please calculate an IV loading dose that was used to achieve a steady state of 6.28 mg/L.
Chapter10: Reconstitution Of Powdered Drugs
Section: Chapter Questions
Problem 9.4P
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A patient was receiving an antibiotic as a constant rate infusion at an infusion rate of 22.01 mg/h. After six times the half life of this drug, the infusion was terminated and the plasma drug concentration was determined as 3.63 mg/L and 2.79 mg/L at 5.1 hours and 8.52 hours, respectively, following the termination of the infusion. The patient started displaying lung infection symptoms again and this antibiotic was to be administered via constant rate IV infusion again. Please calculate an IV loading dose that was used to achieve a steady state of 6.28 mg/L.
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