Biology
12th Edition
ISBN: 9780134813448
Author: Audesirk, Teresa, Gerald, Byers, Bruce E.
Publisher: Pearson,
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Chapter 9.4, Problem 1CSC
Body, Heal Thyself
Ligaments and tendons have a limited capacity for self-repair. They tend to have a meager blood supply and contain only a small number of specialized cells that produce proteins, such as collagen and elastic, that provide flexibility and strength. In Bartolo Colón’s case, the hope was that the stem cells injected into his shoulder and elbow would progress rapidly through the cell cycle, producing large populations of specialized daughter cells that would regenerate his ligaments and tendons. How would mitotic cell division ensure that the daughter cells contained accurate copies of all of Colón’s chromosomes, including the genes that specify all of the proteins needed to repair his arm?
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Chapter 9 Solutions
Biology
Ch. 9.1 - describe the types of cells found in a...Ch. 9.1 - Prob. 2CYLCh. 9.2 - describe the prokaryotic cell cycle and the major...Ch. 9.3 - describe the structure of a eukaryotic chromosome?Ch. 9.3 - describe the functions of telomeres and...Ch. 9.4 - Body, Heal Thyself Ligaments and tendons have a...Ch. 9.4 - describe the events of the eukaryotic cell cycle?Ch. 9.4 - explain the difference between mitotic cell...Ch. 9.5 - What would the consequences be if one set of...Ch. 9.5 - Body, Heal Thyself The precision of mitotic cell...
Ch. 9.5 - describe the steps of mitotic cell division?Ch. 9.5 - describe the usual outcome of mitotic cell...Ch. 9.5 - Prob. 3CYLCh. 9.6 - The saliva of dogs, like the saliva of most...Ch. 9.6 - describe the interactions among growth factors,...Ch. 9.6 - explain how a cell protects against producing...Ch. 9.6 - Yesterday, when Daniel was showering after a...Ch. 9.6 - Prob. 2TCCh. 9 - A cell that remains capable of dividing throughout...Ch. 9 - Prob. 2MCCh. 9 - Prob. 3MCCh. 9 - How does prokaryotic fission differ from...Ch. 9 - Prob. 5MCCh. 9 - The genetic material of all living organisms is...Ch. 9 - Prokaryotic cells divide by a process called...Ch. 9 - Prob. 3FIBCh. 9 - Prob. 4FIBCh. 9 - The four phases of mitosis are _________,...Ch. 9 - Prob. 6FIBCh. 9 - Diagram and describe the eukaryotic cell cycle....Ch. 9 - Prob. 2RQCh. 9 - Prob. 3RQCh. 9 - Define the following terms: centromere, telomere,...Ch. 9 - Prob. 5RQCh. 9 - Prob. 6RQCh. 9 - Prob. 7RQCh. 9 - Most nerve cells in the adult human central...Ch. 9 - Prob. 2AC
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- In your own words, explain how cancer cells differ from normal cells in regard to the following: Molecular controls of the cell cycle (include Cdk and Cdk/cyclin complexes, p53 gene/protein, Rb gene/protein in response)arrow_forwardTumor suppressor proteins can assist in slowing down the cell cycle under appropriate conditions. In humans, the TP53 gene encodes a tumor suppressor called p53. Most mutations in the TP53 gene result in a mutant form of p53 that can no longer function to slow down the cell cycle, which can lead to a cell becoming cancerous. However, some mutant forms of p53 actually possess the ability to increase a cell's resistance to anticancer treatments. Which of the following BEST describes the latter type of mutation? loss-of-function mutation gain-of-function mutation suppressor mutation reverse mutationarrow_forward4) Describe in detail how p53 and MDM2 regulate cell division in a normal, healthy cell. You should describe 1) how these proteins cooperate to allow a cell to go through the cell cycle, 2) how they cooperate to stop the cell cycle, and 3) how they allow the cell cycle to continue again after having stopped it initially. You may use point form if you want.arrow_forward
- During cell division cycle, cells need to monitor the process of DNA replication and segregation of replicated DNA so that these processes are error-free. Some potential errors that could occur include incomplete DNA replication, DNA damage in genome, and uneven separation of replicated genome. These mechanisms that cells used to monitor these processes are referred as the "cell cycle checkpoint, which can control specific Cdk activity to regulate the progression of cell cycle. For the following checkpoint mechanisms, indicate which Cdk activity is attenuated? Also indicate one of the key proteins or protein complexes involved in the following checkpoints. a) DNA damage checkpoint during S-phase b) Mitotic checkpoint during M-phasearrow_forwardHuman cells divide every day for normal growth, replacement of cells, and tissue repair. The dividing cells proceed through the three phases of the cell cycle as shown in the figure. When a person experiences a cut, damaged skin cells secrete a protein called epidermal growth factor (EGF). Epidermal (skin) cells in the vicinity of the injury possess proteins in their cell membranes called epidermal growth factor receptors (EGFR) Cancer can result from disruptions in cell cycle control. Mutations that increase the production of EGFR have been associated with skin cancer of the head and neck. Describe how a mutation outside of the coding region of a gene that encodes EGFR could lead to the overproduction of EGFR protein in a skin cell.arrow_forward(a) the cell cycle is divided into different phases (referred to as M, G0, G1, S and G2); Can you account for what happens during the different parts of the cycle and out of it is checked? ( b) What is the difference between apoptosis and necrosis? ( c) What are caspases and what is their function in the cell?arrow_forward
- Cell division cycle mutations render the mutants unable to continue the cell cycle. This phenotype creates a paradox where mutant cells must also be grown in the lab to further identify the gene and study the role of the protein. How do you think this problem can be solved?arrow_forwardIn normally dividing cells, once chromosomes have been properly segregated via the steps of mitosis, the two resulting “daughter cells” separate. In animal cells (and other cell types without a cell wall) the contractile ring plays a crucial role in the process of cytokinesis. Exactly how the contractile ring is accurately positioned, so as to be located midway between the two poles (ends) of the dividing cell, is still not fully understood, although factors released from the mitotic spindle are thought to play a role.Regardless of the precise positioning mechanism, one key player in the assembly of the contractile ring is the GTP/GDP binding protein Rho. In its active form, Rho can stimulate the activity of the actin-binding protein formin and (via effects on the myosin regulatory light chain) that of myosin II. Given their respective roles, why might activation of formin and myosin II be beneficial as cells assemble a functional contractile ring structure?arrow_forwardHeLa cells are a line of cells grown in laboratory culture that has been used extensively in research. This cell line was originally derived from malignant cervical cancer cells that were removed from a woman named Henrietta Lacks in 1951. They were grown in culture and shipped to research labs around the world where they have been used in many important experiments. Like HeLa cells, many other cell lines were originally taken from cancerous tissue. What are the advantages to using cancer cells for developing cell lines? Why not use normal tissue?arrow_forward
- By what molecular pathway does loss of cell cycle regulation in an organism lead to cancer? What genetic changes can cooperate to accomplish the cancer cell’s escape from the normal balance of cell growth?arrow_forward3) Examine the graph showing the relative percentage normal and cancer cells spend in various stages of the cell cycle. Based on the information in the graphs, infer how cancer cells differ from typical, noncancerous cells. Select ALL that apply. A) Cancer cells do not replicate their DNA. B) Cancer cells replicate their DNA too quickly. C) Cancer cells do not go through interphase during their cell cycle. D) Cancer cells spend more time dividing compared to typical cells. E) Cancer cells do not always grow to the same size as typical cells. more than 1 answer. not gradedarrow_forwardWhile they are similar in many ways, some key differences occur late in the mitotic division. Describe the similarities and differences between the cytokinesis mechanisms found in animal cells versus those in plant cells.arrow_forward
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