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please answer both a and b
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- Calculate the creatinine clearance for Lola, a 69 year old woman who weighs 66kg and has a serum creatinine of 125micromoles/L. Round your answer to 2 decimal places Cockroft Gault equation: [ X (140-age) x (weight in kg)] / serum creatinine (in micromole/L) Where X = 1.04 for females and X = 1.23 for malesAn 84 year old male patient has been given a loading dose of digoxin of 298 micrograms in divided doses by intravenous infusion. He has a creatinine clearance (Ccr) of 34 ml / min. What is the maintenance dose (in micrograms) that this patient should receive? Round your answer to the nearest whole number. Use the formula provided to calculate the maintenance dose. Maintenance Dose = Peak body stores x % daily loss 100 Where: Peak Body Stores = Loading Dose % Daily Loss = 14 + Creatinine clearance (Ccr) 5The instructions for the azithromycin state to reconstitute the 600 mg vial with 3.6 mL until dissolved, to yield a strength of 150 mg/mL, and then to add it to 270 mL of D5W and administer over at least 60 minutes. At what rate will you set the infusion pump if you choose to administer the medication over 90 minutes? order:
- A 30-year-old female patient with uncontrolled hypertension is suspected by an investi- gating endocrinologist of having Conn's syndrome. Results of routine biochemistry were (reference ranges are given in brackets): Sodium Potassium Urea Creatinine Alkaline phosphatase Alanine aminotransferase Albumin Bilirubin Calcium 146 mmol/L 2.1 mmol/L 7.2 mmol/L 146 μmol/L 290 IU/L 20 IU/L 49 g/L 8 μmol/L 2.19 mmol/L (135-145) (3.5-5.0) (3.5-6.6) (70-150) (95-320) (5-42) (35-50) (<17) (2.12-2.62) (a) Are any of the electrolyte concentrations abnormal, and if so what condition is suggested? (b) What further biochemistry investigations would you undertake? Explain your reasoning.In pediatric systolic or pulseless arrest, Epinephrine (1 mg/mL, 1mL amp) is dosed at 0.01mg/kg with a maximum single dose of 1mg every 3-5 minutes until with ROSC. Epinephrine is prepared by mixing 1mg of Epinephrine with 9mL of NSS, and this is the stock solution in which the doses to be administered are aspirated.Patient YH, weighing 26kg, was found unresponsive and pulseless. ACLS was started. What is the appropriate volume (in 2 decimal places) to be aspirated from the Epinephrine admixed solution per dose?A 72-year-old adult patient who weighs 78 kg is prescribed by the doctor “Potassium Chloride 40meq in 1L to run for 8 hours” via the peripheral line for a potassium level of 3.3 mEq/L that was drawn this morning. Note: 10 mEq of potassium chloride increases serum potassium levels by approximately 0.1 mEq/.L The concentration of potassium for intravenous administration via a peripheral line should not exceed 40mmol / 500 mL 10 mEq/hr maximum infusion rate; not to exceed 200 mEq dose/24hr Administration rates above 20mmol/hour require cardiac monitoring. How much will the order medication “Potassium Chloride 40meq in 1L to run for 8 hours” raise the patient's potassium level in a day? Is it still within the normal potassium serum levels, which is 3.5–5.0 mEq/L? Does the order comply with the maximum concentration of potassium to be administered peripherally? Does the order’s infusion rate do not exceed the standard maximum infusion rate? Does the order require cardiac monitoring?
- 6) A male patient has been given a loading dose of digoxin of 1000 micrograms in divided doses by intravenous infusion. He has a creatinine clearance of 47ml/minWhat is the maintenance dose (in micrograms) that this patient should receive? Use the formula provided to calculate the maintenance dose. Maintenance Dose = Peak body stores x % daily loss100Where:Peak Body Stores = Loading Dose% Daily Loss = 14 + Creatinine clearance (Ccr)/5Assume that Ali (same patient in question 1) was prescribed vancomycin 1000 mg every 36 hours. After few days, Steady-state vancomycin concentrations were obtained before and after the fourth dose, and the peak concentration (obtained ½ hour after a 1- hour infusion of vancomycin) was 34 µg/mL while the trough concentration (obtained immediately before dosage administration) was 2.5 pg/mL. Compute a revised vancomycin dose for this patient to provide a steady-state peak concentration of 48 ug/mL and a steady- state trough concentration of 17 pg/mL. a. Estimate new rate constant (Ke) and half-life (t1/2) b. Estimate volume of distribution (Vd) using this equation Cmaxss + Cminss C. Calculate the new dose interval d. Calculate the new doseCalculation: A physician prescribed 125mg progesterone suppository for premenopausal syndrome. You selected a base for suppository to dispense: 40% polyethylene glycol 8000 and 60% polyethylene glycol 400. The average weight of the empty suppository by this base was 2 grams. The dosage replacement factor of progesterone is 0.87. Calculate the weight of one medicated suppository: _________ g per suppository
- Give typed explanation The provider orders a maintenance dose of Magnesium Sulfate 1(g)/(h) to be given using a premixed bag with a concentration of Magnesium Sulfate 4g in 100mL Normal Saline. You will set the pump for a maintenance dose rate of: m(L)/(h)Determine the maintenance dose (in mg) of tobramycin for a 65 year old male patient weighing 85 kg and measuring 5 ft 7, in. in height with a serum creatinine of 2.8 mg/dL. The loading dose desired is 1 mg/kg of ideal body weight and 1.8 mg/kg of ideal body weight for the maintenance dose. Report your answer as a whole number.Sarah who weighs 63 kg is to receive acetylcysteine at a dose of 150 mg/kg infused over 0.25 hours for paracetamol overdose. f The required volume of concentrated acetylcysteine solution (200 mg/mL) has been added to 200 mL of 5% glucose solution. n What is the required infusion rate (mL/min)? (Answer to 2 decimal places.) Answer: 2.9 X You did not give the correct unit. The correct answer is: 16.48 mL/min