A genetic disorder is caused by a LOF mutation (Bm) and epigenetic imprinting of gene B. Through pedigree analysis of many families, researchers have observed the following results: Female carrier B+Bm x B+B+ --> B+Bm and Mother's genotype Father's genotype Children's genotype Children's phenotype Cross 1: B+Bm B+B+ B+Bm , B+B+ some affected, some unaffected Cross 2: B+B+ B+Bm B+Bm , B+B+ always unaffected Based on these results, gene B is imprinted on the: a. maternal b. paternal
Q: A man and both his parents are affected with a disease. His older brother is unaffected. This man…
A: The genes are the primary unit of life. The nucleotide sequence of the genes are responsible for…
Q: In the following pedigree, the indicated trait is caused by which type of allele? ped 1.jpg
A: Answer: Pedigree chart is the chart which explains the genetic history of a family generations.…
Q: Please help a bit confused
A: STR is defined as the Short tandem repeats, also known as microsatellites or simple sequence…
Q: A dihybrid cross involves A. two genetically different individuals B. two individuals that are…
A: Since you've asked multiple questions, we're only answering the first three for you. If you want any…
Q: Fur color in cats is a codominant trait and is located on the X chromosome. Cats can be black,…
A: The presence of this type of characteristic for colour in cats is because of X chromosome…
Q: Hemophilia and colorblindness are both recessive conditions caused by mutations in genes on the X…
A: Sex-linked diseases or diseases are genetic diseases that occur due to the abnormality of genes in…
Q: Polydactly is an autosomal dominant phenotype. In this pedigree, I-2 has one copy of the dominant…
A: A condition in which a baby is born with one or more extra fingers is known as polydactyly. It's a…
Q: cular country in sub-Saharan Africa, a medical study revealed that 0.075% of the country's…
A: Given; The study done in sub Saharan country.0.075% of the country's population are suffering from…
Q: Recessive alleles may be expressed in a child if they are inherited ... (Choose all that apply)…
A: X-linked Recessive diseases are those genetic diseases that are caused by the mutation of genes on…
Q: Below is a pedigree from one family (two parents and eight children). Four of the children…
A: Pedigree chart It is a diagram that represents the occurrence of phenotypes of a particular gene in…
Q: Hemophilia and colorblindness are both recessive conditions caused by mutations in genes on the X…
A: Sex-linked diseases are hereditary sicknesses that happen because of the variation from the norm of…
Q: a certain family with both parents affected with Heberdon’s nodes, a single gene trait characterized…
A: There are many four different modes of inheritance autosomal dominant, autosomal recessive, X linked…
Q: Ill siven the following pedigree below, use Punnett squares for each of the following possibilities:…
A: By the pedigree analysis we can predict the inheritance patterns of a genetically inherited disease.…
Q: You are a gene hunter, trying to find the genetic basis for a rare inherited disease. Examination of…
A: It is given that the rare inherited disease is co-inherited with the markers on the chromosome 7 for…
Q: Pedigree information regarding the incidence of Tay-Sachs within a family is depicted above. The row…
A: We may establish genotypes, classify phenotypes, and predict how a trait will be transferred down in…
Q: n a fox ranch in Scandinavia, a mutation arose that yielded a “platinum” coat color. The platinum…
A: A breeders are not able to produce a pure- breeding platinum foxes even when they tried to cross two…
Q: Jekyll-Hyde Afflicted Spider Curse Afflicted Jekyll-Hyde/Spider Curse Human 2. II 2 III 3.…
A: Pedigree charts are very useful for determining if the disease in question is autosomal dominant or…
Q: Albright syndrome is caused by a mutation in a gene that is imprinted. A is the wild-type allele and…
A: AbstractThe disease results from somatic mutations of the GNAS gene, specifically mutations in the…
Q: A gardener performs a monohybrid cross on two heterozygous orange-fruited tomato plants. Plants…
A: Hi, Thanks For Your Question. Answer : Correct Option Is A
Q: A standard three-point mapping is conducted for recessive mutations in autosomal genes purple eye…
A: Chromosome mapping first introduce the great scientist T.H. Morgan. By the help of recombinant…
Q: You are a genetic counselor, and you received the following pedigree to analyze. You must determine…
A: In this following pedigree shows total 3 generation, 13 family members where 10 members are…
Q: In guinea pigs, black hair is dominant over white hair. If a homozygous black guinea pig (father)…
A: Homozygous: The term homozygous refers to individuals who have the same or identical alleles for a…
Q: You cross two plants and get the following results: Recombinant progeny type A: 43 Recombinant…
A: Crossing over is the exchange of genetic material between non sister chromatid of chromosome causes…
Q: a phenotype aB from an Aabb x aaBb cross? an ab gamete from an aaBB individual?
A: A trait is a characteristic feature that is unique to particular individual. In dihybrid cross , two…
Q: A woman has her personal genome analyzed for the BRCA1 mutation after learning that her father is…
A: Q1. If the father is heterozygous, one of his chromosomes 17 contains the normal allele of the BRCA1…
Q: One of the people on the chart is labeled with the letter A. Which of the following statements…
A: The genes located on the nuclear chromosomes obey the Mendelian law of inheritance. In the human…
Q: If a male bird that is heterozygous for a recessive Z-linked mutation is crossed to a wild type…
A: In case of birds the males are homozygous for the sex chromosome and the genotype is ZZ. The females…
Q: An STR on chromosome 9 is immediately adjacent to a gene involved in a dominant blood disorder (only…
A: Short Tandem repeats (STR): This are short repeated DNA sequences in a human body. This accounts for…
Q: In humans, there are three alleles for blood type: A, B, and O. A and B are codominant over O. A…
A: Blood group inheritance is multiple allelic in nature. Type A blood group can have IA IA/ IA i…
Q: Continuing his experiments, in Miles Morales' genome, the Goblin found similar genes, including one…
A: Here we will calculate the chi-square value to determine, whether invisibility is linked to agility,…
Q: his research exploited the principles of Mendelian genetics combined with the MCR technique to…
A: Mendelian inheritance treats the alleles as independent units. These alleles can be either identical…
Q: An organism of the genotype AaBbCc was testcrossed to a triply recessive organism (aabbcc). The…
A: A gene is a unit of hereditary arranged in thousands on the strands of DNA(deoxyribonucleic acid)…
Q: Nonrecombinent phenotypes: Female/males with gray body/red eyes; females/males with yellow…
A: GIven: Recombinant genotypes are forme by linked genes and their ocmbinations where these…
Q: Albright syndrome is caused by a mutation in a gene that is imprinted. A is the wild-type allele and…
A: Given: A pedigree. Albright syndrome is caused by a mutation in a gene that is imprinted. A - Wild…
Q: Salim and Sara are contemplating having children, but Salim’s brother has galactosemia and Sara’s…
A: Galactosemia is an autosomal recessive disease. Autosomal recessive means that the disease is due to…
Q: Here is a karyotype made from cancer cells. Which of the following abnormalities can be detected?…
A: A karyotype is the representation of an individual's/organism's complete set of chromosomes. These…
Q: Match the term with the correct definition or example Product of a cross between true…
A: There are many words that we come across while discussing genes and gene expressions, like genotype,…
Q: Consider the pedigree below of a dominant autosomal trait. Which individual must be non-penetrant?…
A: A non-penetrant trait is the genetic trait that is present in the genome but does not shows any…
Q: Bicoid is a maternal-effect gene in the fruit fly Drosophila. Recessive mutations in bicoid can…
A: A substance that specifies different fate to the cells due to the difference in their concentration…
Q: An individual heterozygous for four genes, A/a • B/b •C/c • D/d, is testcrossed with a/a • b/b • c/c…
A: A cross is the mating of two people that results in the fusing of gametes and the creation of…
Q: In mice, the presence of AA alleles give rise to the agouti fur color, AAY gives rise to a yellow…
A: Introduction Lethal genes are the genes which are essential for survival. The allele which created…
Q: Write the genotype of the following individuals below based on the pedigree above. Please use…
A:
Q: For an X-linked recessive disease, if an affected male is crossed with an unaffected female who is…
A: "Genetics" is the study of the functioning and main codes of variation and heredity. Inheritance is…
Q: Produce a pedigree diagram to convey the information shown. Gill, has come along to the Genetic…
A: X-linked agammaglobulinemia is an inherited immune system disorder that reduces your ability to…
Q: The ABO blood type locus has been mapped on chromosome 9. A father with blood genotype BO blood and…
A: The presence or absence of the antigens A and B, which are borne on the surface of red blood cells,…
Q: A reciprocal cross is useful when determining which of the following? If a trait is sex-limited…
A: Reciprocal cross It is a concept of crossing F1 hybrids with one of the parents. When F1 is cross…
Q: The Labrador Retriever’s coat colours are black, yellow, and chocolate. Yellow is produced by the…
A: A gene is the basic structural and functional unit of heredity. In humans, each gene consists of two…
Q: Each generation is represented by a Roman Numeral and each individual by a number. Based on the…
A: pedigree is a family chart showing the inheritance of a particular date through several generations…
A genetic disorder is caused by a LOF mutation (Bm) and epigenetic imprinting of gene B. Through pedigree analysis of many families, researchers have observed the following results:
Female carrier B+Bm x B+B+ --> B+Bm and
Mother's genotype | Father's genotype | Children's genotype | Children's |
|
Cross 1: | B+Bm | B+B+ | B+Bm , B+B+ | some affected, some unaffected |
Cross 2: | B+B+ | B+Bm | B+Bm , B+B+ | always unaffected |
Based on these results, gene B is imprinted on the:
a. maternal
b. paternal
Epigenetic imprinting or genomic imprinting is a process where there is the exclusive expression of some specific genes from one parent only. It involves DNA methylation and histone methylation.
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
- A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What if the couple wanted prenatal testing so that a normal fetus could be aborted?A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. What is the chance that this couple will have a child with two copies of the dominant mutant gene? What is the chance that the child will have normal height?A couple was referred for genetic counseling because they wanted to know the chances of having a child with dwarfism. Both the man and the woman had achondroplasia (MIM 100800), the most common form of short-limbed dwarfism. The couple knew that this condition is inherited as an autosomal dominant trait, but they were unsure what kind of physical manifestations a child would have if it inherited both mutant alleles. They were each heterozygous for the FGFR3 (MIM 134934) allele that causes achondroplasia. Normally, the protein encoded by this gene interacts with growth factors outside the cell and receives signals that control growth and development. In achrodroplasia, a mutation alters the activity of the receptor, resulting in a characteristic form of dwarfism. Because both the normal and mutant forms of the FGFR3 protein act before birth, no treatment for achrondroplasia is available. The parents each carry one normal allele and one mutant allele of FGRF3, and they wanted information on their chances of having a homozygous child. The counsellor briefly reviewed the phenotypic features of individuals with achondroplasia. These include facial features (large head with prominent forehead; small, flat nasal bridge; and prominent jaw), very short stature, and shortening of the arms and legs. Physical examination and skeletal X-ray films are used to diagnose this condition. Final adult height is approximately 4 feet. Because achondroplasia is an autosomal dominant condition, a heterozygote has a 1-in-2, or 50%, chance of passing this trait to his or her offspring. However, about 75% of those with achondroplasia have parents of average size who do not carry the mutant allele. In these cases, achondroplasia is due to a new mutation. In the couple being counseled, each individual is heterozygous, and they are at risk for having a homozygous child with two copies of the mutated gene. Infants with homozygous achondroplasia are either stillborn or die shortly after birth. The counselor recommended prenatal diagnosis via ultrasounds at various stages of development. In addition, a DNA test is available to detect the homozygous condition prenatally. Should the parents be concerned about the heterozygous condition as well as the homozygous mutant condition?
- Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior history of the disease. Consider the following pedigree (the darkly colored symbols represent affected individuals): a. Circle the individual(s) in which the mutation most likely occurred. b. Is the person who is the source of the mutation affected by retinoblastoma? Justify your answer. c. Assuming that the mutant allele is fully penetrant, what is the chance that an affected individual will have an affected child?Hemophilia and color blindness are both recessive conditions caused by genes on the X chromosome. To calculate the recombination frequency between the two genes, you draw a large number of pedigrees that include grandfathers with both hemophilia and color blindness, their daughters (who presumably have one chromosome with two normal alleles and one chromosome with two mutant alleles), and the daughters sons. Analyzing all the pedigrees together shows that 25 grandsons have both color blindness and hemophilia, 24 have neither of the traits, 1 has color blindness only, and 1 has hemophilia only. How many centimorgans (map units) separate the hemophilia locus from the locus for color blindness?A woman has her personal genome analyzed for the BRCA1 mutation after learning that her father is heterozygous and carries one mutant allele. What is her chance of inheriting the mutant allele from her father? 0: men cannot transmit genes affecting breast cancer. 25% 50% 75% 100% Among the progeny of a heterozygous round (Aa) x homozygous wrinkled ( aa) cross, three seeds are chosen at random. What is the probability that all three seeds are round? (1/4)3 1/4 (1/2) 3 1/2 A single gene can produce different proteins. True False
- Gene interaction and Epistasis Dog ears may either be drooping or erect. In terms of their barking, some always bark, others sometimes bark, and still other are non-barking. Two dogs from the same species but of different phenotypes were used in the cross: P1 phenotype drooping ears & Non-barking X erect ears & sometimes bark P1 genotype AABB aabb F1 phenotype 100% drooping ears & Non-barking F1 genotype AaBb Mating the male and female from F1 produced: F2 phenotypes F2 genotypes 4 drooping ears & non-barking A_B_ 1 drooping ears & always bark A_bb 2 erect ears & sometimes bark aaB_ aabb Using the same…Both hemophilia (h) and favism (gd) are inherited as X-linked recessive traits. Hemophilia is an inherited disorder of blood clotting, and favism is an inherited hemolytic anemia caused by absence of the enzyme glucose-6-phosphate dehydrogenase. A phenotypically normal woman is known to have the X chromosome genotype h + / + gd. The frequency of recombination between h and gd is 16%. What proportion of sons born to this woman are expected to be phenotypically normal with respect to both hemophilia and favism?Help me create a pedigree of this information: Pedigree analysis: Generation 1: Normal parents (AA x AA) Generation 2: Carrier parents (AA x AS) Generation 3: Affected child (AS x AS) Generation 4: Affected grandchild (SS) This pedigree has two normal parents in the first generation. Second generation carriers carry the sickle cell trait from one parent. The disease is 25% more likely to be inherited in the third generation if both parents have the 'S' allele. If both parents have the 'S' allele, their children will have sickle cell anemia in the fourth generation
- Arabidopsis thaliana is a diploid plant model organism with 2n 10. Please select the number options to match the following number of copies of each gene an Arabidopsis thaliana 1 leaf cell has number of chromosomes an Arabidopsis thaliana leaf cell contains 1. two 2. five number of chromosomes an Arabidopsis thaliana gamete cell contains 3. ten pairs of homologous chromosomes an Arabidopsis thaliana 2 leaf cell containsWild-type mice have brown fur and short tails. Loss of function of a particular gene produces white fur, while loss of function of another gene produces long tails, and loss of function at a third locus produces agitated behavior. Each of these loss of function alleles is recessive. If a wild-type mouse is crossed with a triple mutant, and their F1 progeny is test-crossed, the following recombination frequencies are observed among their progeny. Produce a genetic map for these loci. Brown, short tailed, normal: 955 White, short tailed, normal: 16 Brown, short tailed, agitated: 0 White, short tailed, agitated: 36 Brown, long tailed, normal: White, long tailed, normal: Brown, long tailed, agitated: 46 0 14 White, long tailed, agitated: 933You are given a Drosophila female that looks wild-type but is heterozygous for mutations intan body (t), miniature wings (m), and white eyes (w). You test cross this female with a tanbodied, miniature winged, and white-eyed homozygous mutant male, and you obtain thefollowing 1400 progeny: Phenotype : number+ + + : 608t m w : 516+ m w : 2t + + : 6+ m + : 39t + w : 46+ + w : 81t m + : 102 Calculate the distance between each pair t-m, m-w, and t-w only using the number ofrecombinants between them (i.e. ignoring the gene in the middle). Draw a linear map with thedistances between genes.