() () () () () are short small cationic peptides that act on the cell membranes of invading pathogens. Defensins Lactoferrin Lysozyme Lactoperoxidase Penicillin
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- The two major types of cell-surface receptors that bind tohormone molecules are G-protein linked receptors and_____________________.What are statins? What is their pharmacological function?One such neurotoxin, Sarin (chemical name: propan-2-yl methylphosphonofluoridate) is considered a weapon of mass destruction by the United Nations by virtue of its ability to kill with great efficiency in very low concentrations. a. Where does Sarin have its effect (what is/are its target) and describe the mechanism of action of Sarin (how does it kill)? b. Describe the physical symptoms observed in those stricken with Sarin that are consistent with this mechanism of action. Include flaccid/tonic paralysis, as applicable.
- Discuss the Pharmacokinetics of morphine sulfate using the correct sequence you have chosen in question number one.Question 1. a) Explain how 5 specific fatty acids ultimately generate specific classes of prostaglandins and leukotrienes that are involved in blood pressure, platelet aggregation and inflammation.b) Indicate and explain the specific effects of each of these classes of prostaglandins and leukotrienes on blood pressure, platelet aggregation and inflammation.c) Identify which foods, functional foods and nutraceuticals provide one or more of these 5 fatty acids.What is the biological function of the Neurofibromin-1 (NF1) protein?
- Despite the fact that many peptides have critical physiological functions(e.g., as hormones, neurotransmitters, antibacterial toxins), they are not considered to be ideal as drugs. The following questions illustrate some of the issues that limit the use of peptides as therapeutics.(a) Insulin is a peptide therapeutic used to manage Type 1 diabetes, whichaffects more than 20 million people worldwide according to the International Diabetes Federation. A significant limitation to the broad distribution and use of insulin to treat Type 1 diabetes is the fact that it must be administered by injection rather than orally. Why is insulin administered by injection and not orally?(b) Many of the D-amino acids found in nature have been discovered inbacterially produced peptides that have antibiotic properties. Bacteriasecrete these peptides into their environments to kill competitor bacteriaand thereby gain a selective advantage. Given your answer to part (a) ofthis question, what potential…prpc is a normal protein of our neuronal cell membrane that is sensitive to protease action (ie can be broken down by protease) true or false?What is paroxetine?