Blood clotting is a crucial function for mammalian survival. How do the multi-adhesive properties of fibronectin lead to the recruitment of platelets to blood clots?
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Blood clotting is a crucial function for mammalian survival. How do the multi-adhesive properties of fibronectin lead to the recruitment of platelets to blood clots?
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- In covid-19 myocarditis happened, and endothelial cell is in charge of inhibiting the inflammation, what will happen to the endocardium? It will be affected?a) What is the main structural and functional difference between microbial opsins and mammalian opsins? b) Give one example to each group. c) Why does the discovery of those microbial opsins become a major breakthrough in neuroscience? Edit Format TableA 45-year-old man without a history of bleeding or excessive bruising dies suddenly due to rupture of an aortic dissection. Genetic analysis at autopsy shows a defect in the gene for fibrillin. Which of the following events most likely occurs with defective fibrillin? (A) Elastic fibers in the extracellular matrix are not correctly formed (B) Hyaluronic acid in proteoglycans is not sulfated on the proper hydroxyl residues (C) Intermediate filaments are not assembled in endothelial cells (D) Shorter side chains of chondroitin sulfate are present on the proteoglycans (E) Tubulin is not polymerized correctly due to the lack of GTP in endothelial cells
- Synaptic vesicles release into the synapse to give the message to the post synaptic neuron?Multicellular organisms:a) are larger in size than unicellular organisms b) can do a wider variety of functionsFor a stroke patient with hypertension who is a candidate for recombinant tissue plasminogen activator rt pa which blood pressure control strategy is appropriate?Poliovirus is highly cytopathic both in cultured cells and in animals. Inoculation of mice with poliovirus leads to a robust antibody and cellular response. Explain why mice infected with a poliovirus mutant that cannot cause cell death have poor antibody and cellular responses. What would be one strategy to restore robust antibody and cellular responses in mice infected with this mutant virus?Which isoenzyme of creatine kinase (CK) is primarily found in cardiac muscle? 1) CK-BC 2) CK-MB 3) CK-BB 4) CK-MM no references, just homework
- The anticlotting property of heparin is partly the result of the negative charges it carries. ( Q.) Which type of heparin is a better anticoagulant, one with a high or a low degree of polymerization?Amoeboid cells that migrate through our tissues, such as the class of white blood cells known as neutrophils, often do so in a directed manner, triggered, for instance, by chemical signals released by pathogens such as bacteria. Directed migration in response to a chemical stimulus is known as chemotaxis. Part of an efficient chemotactic response is the ability of cells to polarize. As is the case with our structurally-polar polymers like F-actin or microtubules, polarization here refers to an asymmetry in the cells, rather than an electrical charge. In this case, it involves one part of the cell becoming the “front” (or leading edge) and another the rear. In a well-polarized, migrating cell, it’s been observed that an active form of Rac (which, in turn, can activate ARP 2/3) is concentrated towards the front of the cell, whereas an active form of Rho (which, in turn, can activate formin, inhibit ADP, and activate myosin II) is found toward the rear of the cell. Based on your…Amoeboid cells that migrate through our tissues, such as the class of white blood cells known as neutrophils, often do so in a directed manner, triggered, for instance, by chemical signals released by pathogens such as bacteria. Directed migration in response to a chemical stimulus is known as chemotaxis. Part of an efficient chemotactic response is the ability of cells to polarize. As is the case with our structurally-polar polymers like F-actin or microtubules, polarization here refers to an asymmetry in the cells, rather than an electrical charge. In this case, it involves one part of the cell becoming the “front” (or leading edge) and another the rear. In a well-polarized, migrating cell, it’s been observed that an active form of Rac (which, in turn, can activate ARP 2/3) is concentrated towards the front of the cell, whereas an active form of Rho (which, in turn, can activate formin, inhibit cofilin/ADP, and activate myosin II) is found toward the rear of the cell. Based on your…
- α-Bungarotoxin is a powerful neurotoxin found in the venom of a poisonous snake (Bungarus multicinctus). It binds with high specificity to the acetylcholine receptor (AChR; an integral membrane protein) andprevents its ion channel from opening. This interaction was used to purify AChR from the electric organ of torpedo fish.(a) Outline a strategy for using α-bungarotoxin covalently bound to chromatography beads to purify the AChR protein. (b) Outline a strategy for the use of [125I]α-bungarotoxin to purify the AChR protein.You want to understand how the density of P-selectin in blood vessel walls affects the rolling interactions of neutrophils when they are subjected to hydrodynamic drag forces in the blood. You introduce P-selectin into a synthetic lipid bilayer and attach it to a glass slide mounted in a flow chamber. This arrangement allows you to measure neutrophil attachment at different densities of P-selectin and at different flow rates. At high densities, from 30 to 400 P-selectin molecules per µm², the neutrophils attached to the membrane and rolled very slowly and jerkily in the direction of the flow (see cell 1 in the figure). At the same flow rate, but at a density of 15 P-selectins per µm², the neutrophils behaved differently: they either moved at the flow rate of the medium or were transiently tethered-horizontal lines marked by t-before moving again (cell 2 in the figure). Neutrophils showed this same behavior at a density of 1 P-selectins per μm² and half the flow rate: moving at the flow…You’ve just come from your annual physical and are alarmed to find that you’ve developed a number of plaque blockages in your coronary arteries. Which intervention might decrease your risk of having a heart attack? (A) Take a drug that reduces the recycling of LDL receptors back to the cell surface.(B) Drink more alcohol, as ethanol has been shown to increase the synthesis of SREBP. (C) Increase your intake of fish to increase your circulating HDL levels.(D) Increase your intake of red meat to increase your circulating LDL levels.(E) Take a drug that decreases the KM of HMG-CoA reductase for HMG-CoA.