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Compare the binding of MHC molecules to antigen with the binding of BCR to antigen.
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- Draw a schematic diagram of a typical IgG molecule and label each of the following parts: H chains, L chains, intrachain disulfide bonds, hinge, Fab, Fc, and all the domains. Indicate which domains are involved in antigen binding.Name the two types of antibody light chains.Describe the reason that it is useful that antibodies have two antigen binding arms.
- Describe the term "in-frame" and also the reason that it would be necessary for the generation of diversity in antigen receptors.Diagram the structure of an antibody. What parts bind toantigens? Why does each antibody bind only to one or afew specific antigens?List the steps of MHC class I peptide formation and assembly.