Dimethoate is a commonly used agrochemical. However, chronic exposure to it can causean individual to develop hyper-ß-alaninemia (i.e., excessive alanine) in the muscles. Wouldhyper-ß-alaninemia impact glycolysis?O Yes, pyruvate kinase would be suppressed as a consequence of hyper-ß-alaninemia.Yes, glucokinase would be suppressed as a consequence of hyper-ß-alaninemia.No, hyper-ß-alaninemia would not impact glycolysis.Yes, hexokinase would be suppressed as a consequence of hyper-ß-alaninemia.O Yes, phosphofructokinase would be suppressed as a consequence of hyper-ß-alaninemia.

Hyper-ß-alaninemia is a condition characterized by excessive alanine in the muscles. In the context…

Answered: Dimethoate is a commonly used…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter27: Metabolic Integration And Organ Specialization

Section: Chapter Questions

Problem 17P

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Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is inhibited byÂ· NIADH. Pyruvate dehydrogenase is inhibited by AÎ¤Î¡. Citrate synthase is inhibited by NADH. Succinyl-CoA activates citrate synthase. Acetyl-CoA activates pyruvate carboxylase.
What type of regulation would be expected when anaerobic metabolism is occurring in the muscle? Select all that apply. O Activation of pyruvate dehydrogenase kinase O Increased levels of calcium to activate pyruvate dehydrogenase phosphatase O Phosphorylation of pyruvate dehydrogenase O Inhibition of pyruvate dehydrogenase complex O Increased levels of NADH to activate citrate synthase O Increased levels of NADH to inhibit alpha-ketogluterate dehydrogenase complex O Increased levels of acetyl CoA to activate pyruvate carboxylase for gluconeogenesis
Which of the following is TRUE? O Both AMP and ADP are negative regulators of glycogenolysis. ATP shifts the curve of glycogen phosphorylase to the left. O Citrate binds covalently to acetyl CoA carboxylase. Phosphofructokinase-1 is an allosterically regulated enzyme in glycolysis. The carnitine shuttle is positively regulated by Malonyl CoA.
To begin the TCA cycle, pyruvate must be converted into acetyl-Coenzyme A (acetyl-CoA) by the enzyme complex of pyruvate dehydrogenase. This complex requires 5 different coenzymes to function properly. What are they?
A patient exhibiting all the symptoms of beriberi is placed on a thiamine-enriched diet; however, the symptoms do not disappear. Genetic screening suggests a defect in pyruvate dehydrogenase phosphatase. Briefly explain why the genetic defect caused beriberi symptoms andy why thiamine supplementation had no effect.
In the pyruvae dehydrogensae complex, acetyl-coa is released by the dihydrolipoyl transacetylase activity. What is the purpose of the following enzymatic activity.
Which of these are components of animal fatty acid synthase (FAS)? ✔B-ketoacyl reductase enoyl reductase acetyl transacylase acyl CoA synthetase 3-hydroxyacyl dehydratase acyl CoA dehydrogenase Incorrect Fatty Acid Synthase (this diagram based on fungal FAS)
I still struggle to understand the link between beta-oxidation and ketogenesis pathways. So under low glucose condition, cell will not be able to run glycolysis but instead gluconeogenesis to make glucose, so citric acid cycle will also be reduced because there is not enough acetyl CoA to combine with oxaloacetate, thus leading to Increases beta oxidation to break down fatty acids for acetyl CoA production. Then why can't acetyl CoA be used directly from here for TCA but through ketone bodies? Furthermore, what conditions lead to activation for the production of ketone bodies, and during that production does it recycle CoA, and if so, what pathway will that CoA be used for? Finally, when ketogenesis occurs, how are other pathways affected (glycolysis, gluconeogenesis, capacity of TCA, CoA availability, beta oxidation, glucose take up by liver cells?
How similar of an effect would a mutation in pyruvate dehydrogenase have, compared to a mutation in pyruvate carboxylase that blocks its ability to be regulated by acetyl-CoA?
Fructose-2,6-bisphosphate is an activator of and an inhibitor of O phosphofructokinase; hexokinase O fructose bisphosphatase; phosphofructokinase O phosphofructokinase; fructose bisphosphatase O glucose-6-phosphatase; pyruvate kinase O pyruvate kinase; phosphoenolpyruvate carboxykinase
Which of the following is NOT a fate of pyruvate in metabolism? .. Conversion to alanine as its storage form or for use by peripheral tissues such as skeletal muscles. Conversion to acetyl CoA for complete oxidation in the TCA cycle. Conversion to oxaloacetate in gluconeogenesis Conversion to lactate in a completely anaerobic process. L. Conversion to phophoenolpyruvate for the synthesis of glucose
What is(are) the only active site(s) not used in the second round of fatty acid synthase? Select all that apply. Group of answer choices Acetyl-CoA ACP Transacylase Beta-Ketoacyl- ACP Synthase Beta-Ketoacyl- ACP Dehydrase Palmitoyl thioesterase Malonyl-CoA ACP Transacylase Enoyl-ACP Reductase

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