Mitochondrial beta-oxidation of a fully saturated 18-carbon-long (linear) fatty acyl-CoA produces what? O9 acetyl-CoA, 10 NADH, and 10 FADH2 8 acetyl-CoA, 9 NADH, and 8 FADH2 O9 acetyl-CoA, 8 NADH, and 8 FADH2 O9 acetyl-CoA, 9 NADH, and 9 FADH
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- Ethanol as a Source of Metabolic Energy (Integrates with Chapters 19 and 20.) Acetate produced in ethanol metabolism can be transformed into acetyl-COA by the acetyl thiokinase reaction: Acetate+ATP+CoASHacetyleCoA+AMP+PPiAcetyle-CoA then can enter the citric acid cycle and undergo oxidation to 2 CO2by this route, assuming oxidative phosphorylation is part of the process? (Assume all reactions prior to acetyl-CoA entering the citric acid cycle occur outside the mitochondrion). Per carbon atom, which is a better metabolic fuel, ethanol or glucose? That is, how many ATP equivalents per carbon atom are generated by combustion of glucose versus ethanol to CO2?Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is inhibited by· NIADH. Pyruvate dehydrogenase is inhibited by AΤΡ. Citrate synthase is inhibited by NADH. Succinyl-CoA activates citrate synthase. Acetyl-CoA activates pyruvate carboxylase.B-oxidation of a 15:0 fatty acid will result in the production of O 7 acetyl CoA, 7 FADH2, and 7 NADH O 7 acetyl CoA, 1 propionyl CoA, 8 FADH2, and 8 NADH 6 acetyl CoA, 1 propionyl CoA, 7 FADH2, and 7 NADH 6 acetyl CoA, 1 propionyl CoA, 6 FADH2, and 6 NADH
- Calculate the number of ATPS generated from the metabolic oxi- dation of the four carbons of acetoacetyl-CoA to CO,. Now consider the homolog derived from oxidation of an odd-numbered carbon chain, namely propionoacetyl-CoA. Calculate the net ATP yield from oxidation of the five carbons of this compound to CO,.The diagram on the right compares the O2 uptake activity of mitochondria isolated from cultures of (wt) STHdhQ7/Q7 and mutant STHDHQ111/Q111 striatal neuronal progenitor cells, as introduced in Question 1. Panels A and B be- long to wt mitochondria and Panels C and D be- long to HD mitochondria. The isotonic medium was buffered to pH 7.4 with inorganic phosphate. Respiration is supported initially by addition of py- ruvate (+ malate) at t = 0, followed by additions of ADP (sufficient to consume all of the O2 in the incubation medium), R (rotenone), S (succinate), and O (oligomycin). For Panels A and C, Ca2+ had been added to a concentration of 0.9 µM, Ca2+ 2. B A WT 400 ADP ADP 450 300 - 300 200 Ca2 10 uM 150 100 - C HD 400 ADP R ADP R SO 450 300 - V s Ca2 10 uM 300 200 - 150 100 - while for mitochondria in Panels B and D, had been added to the medium to a final concen- Time 20 min tration of 10 µM, sufficient to require translocation into the mitochondrial matrix by the Ca2+…Beta-Oxidation of a 15:14⁹ fatty acid will result in the production of which of the following? 7 acetyl CoA, 1 propionyl CoA, 6 FADH2 and 6 NADH 7 acetyl CoA, 6 FADH2 and 6 NADH 6 acetyl CoA, 1 propionyl CoA, 6 FADH2 and 6 NADH 6 acetyl CoA, 1 propionyl CoA, 5 FADH2 and 6 NADH 6 acetyl CoA, 6 FADH2 and 6 NADH
- Fatty acids are activated for breakdown through the action of acyl-CoA synthestase. Which of the following statements regarding acyl-CoA synthetase is not true? ● It catalyzes the addition of CoA to the fatty acid One of the products of the reaction is ADP. O The free energy change for the reaction catalyzed by this reaction is close to 0 kJ/mol, but the subsequent hydrolysis of pyrophosphate drives the reaction forward. O The reaction results in the formation of a thioester bond.If oxidation of acetyl-CoA yields 10 ATPs per mole through the citric acidcycle, how many ATPs will be derived from the complete metabolic oxidation of 1 mole of alanine in a mammal? Would the corresponding energyyield in a fish be higher or lower? Why? How much energy would bederived from the metabolic oxidation of 1 mole of isoleucine to CO2, H2O,and NH3? Of tyrosine?The synthesis of the activated form of acetate (acetyl-CoA) is carried out in an ATP-dependent process: Acetate + CoA + ATP → acetyl-CoA + AMP + PPi (a) The ∆G’o for the hydrolysis of acetyl-CoA to acetate and CoA is - 32.2 kJ/mol and that for hydrolysis of ATP to AMP and PPi is - 30.5 kJ/mol. Calculate ∆G’o for the ATP-dependent synthesis of acetyl-CoA. (b) Almost all cells contain the enzyme inorganic pyrophosphatase, which catalyzes the hydrolysis of PPi to Pi. What effect does the presence of this enzyme have on the synthesis of acetyl-CoA? Explain.
- 10 ATP/Acetyl-CoA * 2 acetyl-CoA = 20 ATP 1 GTP/ Acetyl-CoA * 2 acetyl-CoA = 2 GTP 1,5 ATP/ FADH2 * 1 FADH2= 1,5 ATP 2,5 ATP/ NADH * 3 NADH = 7,5 ATP 7,5 + 1,5 + 20 = 29 ATP och 2 GTP All of this is round off, how to calculate without rounding off? 2-Acetyl-CoA and 15 subunitsHow much ATP is produced from the complete B-Oxidation of myristic acid (C14H2802)? Activation of Fatty Acid ACCOA x (10 ATP/ACCOA) FADH₂ x (1.5 ATP/FADH₂) = NADH x (2.5 ATP/NADH) : = = -2 ATP ATP ATP ATP TOTAL ATP C18 CH, (CH₂)₁4-CH₂-CH₂-C-S-COA || FAD →FADH₂ CH₂(CH₂)₁4-CH=CH-C-S-CoA Each loop of the pathway represents a repetition of Steps 1-4. H₂O OH CH₂(CH₂)₁4-CH-CH₂-C-S-CoA || - NAD+ →→NADH+ H 0 CH3-(CH₂) 14 C-CH₂-C-S-CoA 0 || C16 CH₂(CH₂)14-C-S-CoA COA-SH Acyl CoA trans-Enoyl COA L-B-Hydroxyacyl CoA B-Ketoacyl COA H₁-C-S- + CH₂-C-S-CoA Acetyl CoA New acyl COA C₁4+ Acetyl CoA C12+ Acetyl CoA CO+ Acetyl CoA Cg+ Acetyl CoA C + Acetyl COA C₁ + Acetyl COA 2 Acetyl COAMetabolizing a fatty acid via the B-oxidation pathway will generate acetyl CoA, NADH and FADH₂. Based on your biochemical knowledge, the major metabolic intermediate will enter cellular respiration in [Select] and the reduced coenzymes will enter cellular respiration in [Select] Could a mature red blood cell perform the ß-oxidation pathway? Yes, in their cytoplasm.