choose the correct answer. Not being able to inhibit pyruvate dehydrogenase, despite high levels of NADH or ATP, could cause the following issues:Pyruvate would be quickly converted to acetyl coA, which would encourage more Krebs cycle activity. However, the glycolytic shunts would also work more quickly,so that glycogenesis and the pentose phosphate pathway would be overused.Pyruvate would be quickly converted to acetyl coA, which would encourage more Krebs cycle activity. However, the person would be unable to use the glycolyticshunts so that glycogenesis and the pentose phosphate pathway wouldn't work.Pyruvate would build up in the cytoplasm, which would encourage more Krebs cycle activity. The glycolytic shunts would also work more quickly, so thataminogenesis and fatty acid synthesis would be overused.Pyruvate would build up in the cytoplasm, which would cause the Krebs cycle to slow down, as well as the glycolytic shunts. That means that aminogenesis and fattyacid synthesis would be impaired.

pyruvate dehydrogenase complex is the enzyme complex which convert pyruvate to Acetyl CoA, NADH2 AND…

Answered: Not being able to inhibit pyruvate…

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter19: The Tricarboxylic Acid Cycle

Section: Chapter Questions

Problem 22P: Study Figure 19.18 and decide which of the following statements is false. Pyruvate dehydrogenase is...

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A fatty acid (a long straight-chain carboxylic acid with an even number of carbons) is metabolized to acetylCoA, which can then enter the citric acid cycle to be further metabolized. A fatty acid with an odd number of carbons is metabolized to acetyl-CoA and one equivalent of propionyl-CoA. Propionyl-CoA cannot enter the citric acid cycle. Two coenzyme-requiring enzymes are needed to convert it to succinyl-CoA, a compound that can enter the citric acid cycle. Write the two enzyme-catalyzed reactions and include the names of the required coenzymes.
To begin the TCA cycle, pyruvate must be converted into acetyl-Coenzyme A (acetyl-CoA) by the enzyme complex of pyruvate dehydrogenase. This complex requires 5 different coenzymes to function properly. What are they?
How similar of an effect would a mutation in pyruvate dehydrogenase have, compared to a mutation in pyruvate carboxylase that blocks its ability to be regulated by acetyl-CoA?
Identify the Krebs cycle enzyme that consumes a 3-carbon substrate molecule, producing a 2- carbon product molecule (attached to acetyl-CoA), along with NADH, and one molecule of CO2. succinyl CoA synthetase a-ketoglutarate dehydrogenase pyruvate dehydrogenase isocitrate dehydrogenase malate dehydrogenase
Complete the following description of the mechanism of the pyruvate dehydrogenase complex by using words provided. Not all words will be used. Each word will be used only one time. Three enzymes of the pyruvate dehydrogenase complex work together to catalyze the production of Acetyl CoA from Pyruvate. First, a 2-carbon unit composed of Carbons # ____ and ____ of Pyruvate are added to the co-enzyme ______ and whereas Carbon # ______ leaves as CO. The C-2 unit together with the co-enzyme is called ______ .The C-2 unit is then transferred to the 2nd co-enzyme ____, which is initially in it ___ state. The enzyme that catalyzes this step is ______.From here, the C-2 unit is transferred to form a _____ linkage with CoA-SH to generate_____
Oxaloacetate can be directly converted to [PEP/glucose/citrate/malate] in the process of gluconeogenesis. Oxaloacetate can be directly converted to [PEP/glucose/citrate/ malate] upon condensation with acetyl-CoA. Oxaloacetate can be directly converted to [PEP/glucose/citrate/malate] by a reversible enzyme in the citric acid cycle. Oxaloacetate, via many enzymes, is an important source of [PEP/glucose/citrate/malate] in the liver for tissues that rely on carbohydrates for the fuel source. help fill in the blanks
All of the following enzymes catalyze a committed step EXCEPT: HMG-CoA reductase Fatty acyl-CoA synthetase Acetyl-CoA carboxylase I Pyruvate dehydrogenase complex All of the above enzymes catalyze a committed step The brain can directly use all of the following chemicals as energy source EXCEPT: Acetoacetate b-hydroxybutyrate Glucose Fatty acids All of the above can directly be used by the brain as energy source
I still struggle to understand the link between beta-oxidation and ketogenesis pathways. So under low glucose condition, cell will not be able to run glycolysis but instead gluconeogenesis to make glucose, so citric acid cycle will also be reduced because there is not enough acetyl CoA to combine with oxaloacetate, thus leading to Increases beta oxidation to break down fatty acids for acetyl CoA production. Then why can't acetyl CoA be used directly from here for TCA but through ketone bodies? Furthermore, what conditions lead to activation for the production of ketone bodies, and during that production does it recycle CoA, and if so, what pathway will that CoA be used for? Finally, when ketogenesis occurs, how are other pathways affected (glycolysis, gluconeogenesis, capacity of TCA, CoA availability, beta oxidation, glucose take up by liver cells?
In the pyruvae dehydrogensae complex, acetyl-coa is released by the dihydrolipoyl transacetylase activity. What is the purpose of the following enzymatic activity.
When the acetyl-CoA produced during ß-oxidation in the liver exceeds the capacity of the citric acid cycle, the excess acetyl-CoA forms ketone bodies acetone, acetoacetate, and D-b-hydroxybutyrate. This occurs in severe, uncontrolled diabetes: because the tissues cannot use glucose, they oxidize large amounts of fatty acids instead. Although acetyl-CoA is not toxic, the mitochondrion must divert the acetyl-CoA to ketone bodies. What problem would arise if acetyl-CoA were not converted to ketone bodies? How does the diversion to ketone bodies solve the problem?
alpha-ketoglutarate dehydrogenase will do which of the following: Select one: a. Pyruvate is decarboxylated to become acetyl-CoA producing NADH and Carbon dioxide b. Succinate is oxidized to become fumarate forming FADH2 c. Succinyl-CoA becomes Succinate and forms one ATP molecule and Coenzyme A-SH d. Oxaloacetate combines with the acetyl from acetyl-CoA to produce Citric acid(citrate) e. Malate is oxidized to become oxaloacetate forming NADH f. Isocitrate and then decarboxylated and oxidized to produce alpha-ketoglutarate, Carbon dioxide and NADH g. Citrate is rearranged to become Isocitrate h. Fumarate is combined with water to become Malate i. alpha-ketoglutarate is oxidized and decarboxylated to produce Succinyl-CoA, Carbon dioxide and NADH
Fatty acid biosynthesis begins with the condensation of a two-carbon acetyl residue from acetyl-COA and oxaloacetate, while oxidation leads to the release of two carbon units, acetyl-CoA and fatty acyl-CoA. However, these two processes are not simple reversal. Compare and contrast these two pathways.

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