oteins, assembled in a stepwise r Once the core octamer has been formed, DNA wraps around it to form a nucleosome core particle. Whi ollowing is the correct formula of the histones in the nucleosome? .. 2 (H2A + H2B + H3 + H4) + H1 . H2A + H2B + H3 + H4 + H1 C. D. 8 (H2A + H2B + H3 + H4) + 2 H1 None of the above

oteins, assembled in a stepwise r Once the core octamer has been formed, DNA wraps around it to form a nucleosome core particle. Whi ollowing is the correct formula of the histones in the nucleosome? .. 2 (H2A + H2B + H3 + H4) + H1 . H2A + H2B + H3 + H4 + H1 C. D. 8 (H2A + H2B + H3 + H4) + 2 H1 None of the above

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter8: The Structure, Replication, And Chromosomal Organization Of Dna

Section: Chapter Questions

Problem 25QP: Discuss the levels of chromosomal organization with reference to the following terms: a. nucleotide...

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Histone genes are unusual among eukaryotic genes because they do not have introns, and histone mRNAs do not have poly(A) tails. Moreover, in almost all eukaryotes, histone genes are arranged in multiple tandem domains, each domain carrying one copy of each of the five histone genes. Explain these features in terms of the special requirements for histone synthesis.
Protein A has a pl of 6.5 and appears to form tetramers. Protein B has a pl of about 8.5, and appears to form octamers. Which one has the potential to function as a Histone based on this information? Protein A Protein B O Both Neither
All of the following statements regarding nucleosomes are true EXCEPT A each bead-like structure contains 8 molecules of histones H1, H2A, H2B, H3 and H4 the bead like structures are made up of core histones wrapped around by the DNA strands the histone proteins in the nucleosomes contain positively charged amino acids that interact with the negatively charged DNA D the bead like structures are linked to each other by the DNA chain
Mention the function of non-histone protein.
Mammals contain a diploid genome consisting of at least 109 bp. If this amount of DNA is present as chromatin fibers, where each group of 200 bp of DNA is combined with 9 histones into a nucleosome and each group of 6 nucleosomes is combined into a solenoid, achieving a final packing ratio of 50, determine (a) the total number of nucleosomes in all fibers, (b) the total number of histone molecules combined with DNA in the diploid genome, and (c) the combined length of all fibers.
Histone proteins contain tail amino acids that are positively charged. Which of the following characteristics of DNA would best support tight interactions between DNA and histones? O A. DNA 5' and 3' ends have negative charge responsible for stabilizing interactions with histones O B. the DNA backbone has a net negative charge that is attracted to the histones O .the minor groove in DNA fits around the spherical shape of the histones O D. the histone octamer is attracted to the deoxyribose in DNA
Assuming that the histone octamer forms a cylinder 9 nm in diameter and 5 nm in height and that the human genome forms 32 million nucleosomes, what volume of the nucleus (6 μm in diameter) is occupied by histone octamers?
To hold bacterial DNA in a more compact configuration, specificproteins must bind to the DNA and stabilize its conformation.Several different proteins are involved in this process. Some of theseproteins, such as H-NS, have been referred as histone-like, due totheir functional similarity to the histone proteins found in eukaryotes.Based on your knowledge of eukaryotic histone proteins, whatbiochemical properties would you expect bacterial histone-likeproteins to have?
An old genetic observation is that a normally active gene will be silenced if it is moved by transposition or crossing over from an uncondensed (euchromatic) region to a heavily condensed (heterochromatic) region of a chromosome. Assume the euchromatic chromatin containing the active gene is surrounded by heterochromatic chromatin immediately after insertion. Please explain in terms of the control of histone modification why the normally active gene is silenced when it becomes surrounded by condensed regions. (Do not explain how histone modification causes chromatin condensation.)
Give at least one example of a chromosomal structureor function affected by the following mechanisms formodulating chromatin structure:a. Posttranslational changes of the normal histonesfound in the nucleosome
You discover a histone variant that has more positive charge than conventional histone proteins. What effect do you predict this histone variant would have when it is inserted into chromatin? A decrease in the strength of histone-DNA interaction, making chromatin less condensed and increasing gene expression An increase in the strength of histone-DNA interaction, making chromatin less condensed and decreasing gene expression An increase in the strength of histone-DNA interaction, making chromatin more condensed and decreasing gene expression O A decrease in the strength of histone-DNA interaction, making chromatin less condensed and decreasing gene expression
What are histone proteins, and how are their DNA binding properties regulated. Indicate if there are any modification(s) that comes on and off that regulates how tightly or loosely the Histone proteins are bound to DNA.