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Name: fill in the blanksThe ( ) protein in a signal transduction
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Description: fill in the blanksThe ( ) protein in a signal transduction pathway interact with adenylate cyclase to form 2nd messenger ( ) and with phospholipase C to form the two 2nd messengers ( ) and ( )

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Biochemistry

The ( ) protein in a signal transduction pathway interact with adenylate cyclase to form 2nd messenger ( ) and with phospholipase C to form the two 2nd messengers ( ) and ( )

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter4: Principles Of Neural And Hormonal Communication

Section: Chapter Questions

Problem 5RE: Second-messenger systems ultimately bring about the desired cell response by inducing a change in...

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Many phospholipase C enzymes contain pleckstrin homology (PH) domains. What is the function of these domains? (a) Bind DNA, (b) Phosphorylate proteins, (c) Phosphatase proteins, (d) Bind proteins, (e) Bind phosphatidylinositol. I note that PH domain interacts with 3’phosphoinositides, contributing to recruitment of AKT to the plasma membrane, thus thinking of the possible answer (e) which is phosphatidylinositol (ie. PI) of a family of lipids consisting PIP3 or PIP2 etc. However, I wonder if “3’phosphoinositides” is the same as “PIP3”.As an alternative, I note that PH domain is a protein domain that occurs in a wide range of proteins involved in intracellular signaling, I tend to choose (d) as an answer also.I should be grateful for receiving your expert advice as to which (a) to (e) is the best answer.