The Warburg effect is generally observed in cancer cells as a consequence of pyruvate dysmetabolism. Which of the following statements is inaccurate in describing the metabolic switch termed the Warburg effect?   P53 function in regulation of glycolysis is lost, preventing proper cellular response of apoptosis Lactate production becomes the major fate of pyruvate Diminished oxidative phosphorylation in the matrix leads to enhanced non-oxidative ATP production Glycolytic flux is increased Pyruvate levels are diminished through the PDHC Pyruvate carboxylase is activated HIF1transcriptional activation

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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The Warburg effect is generally observed in cancer cells as a consequence of pyruvate dysmetabolism. Which of the following statements is inaccurate in describing the metabolic switch termed the Warburg effect?
 
P53 function in regulation of glycolysis is lost, preventing proper cellular response of apoptosis
Lactate production becomes the major fate of pyruvate
Diminished oxidative phosphorylation in the matrix leads to enhanced non-oxidative ATP production
Glycolytic flux is increased
Pyruvate levels are diminished through the PDHC
Pyruvate carboxylase is activated
HIF1transcriptional activation leads to increased levels of pyruvate dehydrogenase kinase and lactate dehydrogenase, while enhancing lactate export from the cytosol
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