Why doesn't Cdk1 active immediately upon binding to cyclin B? What other components of the cell’s regulatory machinery could explain the delay in activation of the kinase activity?
Why doesn't Cdk1 active immediately upon binding to cyclin B? What other components of the cell’s regulatory machinery could explain the delay in activation of the kinase activity?
It includes cell division, replication and growth. All these processes should be carried out in a regulated manner in order to ensure correct division and production of intact progeny. Cell cycle is a sequence of events by which a cell duplicates its genetic material, synthesizes other cell constituents and divides into two daughter cells.
Cell division is of two types : mitosis is where the parental cell divides into two cells with identical genetic material and meiosis involves the reduction of the parental genetic material into equal halves.
Cell cycle has two phases, interphase and M (mitotic) phase. The interphase is divided into G1 (gap 1), G2 (gap 2) and S (synthesis) phase.
G1 - It represents the time interval between mitosis and initiation of DNA (deoxyribonucleic acid) replication. It is the longest phase since all the components required for DNA replication and other processes are being made.
S - It is the phase of the cell cycle where DNA replication occurs.
G2 - In this phase all the necessary cell constituents like proteins are synthesized preparing the cell for division.
M phase - All the components of the cell undergo rearrangements. It has four stages: prophase, metaphase, anaphase and telophase. Farmer and Moore are the two scientists who coined the term meiosis. It involves one round of replication followed by two rounds of chromosomal segregation. Meiosis 1 and meiosis 2 are the two divisions of meiosis. Prophase 1, metaphase 1, anaphase 1 and telophase 1 are the four stages of meiosis 1. This is followed by interkinesis after which meiosis occurs. Meiosis is seen in the germ cells. It has a long prophase and produces genetically different daughter cells.
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