Write note on the circled events of the excitation contraction coupling shown in the diagram below. Sarcolemma T-tubule Myosin Ca++ 4 Ca Cat 3 TN-I 2 TN-C -TN-T SR DHP receptor Actin TM SERCA RyR RK '17

Write note on the circled events of the excitation contraction coupling shown in the diagram below. Sarcolemma T-tubule Myosin Ca++ 4 Ca Cat 3 TN-I 2 TN-C -TN-T SR DHP receptor Actin TM SERCA RyR RK '17

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter8: Muscle Physiology

Section: Chapter Questions

Problem 10RE

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Concept explainers

Muscle Action

A change in the body or a bodily organ as a result of its functioning is referred to as an action. Muscle action can be defined as the specific movement of a bodily part generated by the contraction of a muscle. The muscle proteins actin and myosin are the important contractile proteins involved in muscle action. Muscle contraction, in addition to movement, serves several other important functions in the body, including posture, heat generation, and joint stability. Muscle contraction maintains posture, which includes standing and sitting.

Question

Write note on the circled events of the excitation contraction coupling shown in the diagram
below.
Sarcolemma
T-tubule
Myosin
Ca++
4 Ca
Cat
3
TN-I
2
TN-C
-TN-T
SR
DHP
receptor
Actin
TM
SERCA
RyR
RK '17

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Table1.Contractionofsmoothmusclebythreeagonists Contractileresponse(mm) Loglagonist] (M) -10 -9 -8.5 -8 -7.5 -7 -6.5 -6 -5.5 -5 -4.5 -4 agonist-1 0.2 1.8 4 9.8 14.8 18 19.6 19.4 20 20 20 20 agonist-2 0.2 1 2.6 4 7.6 8.8 9.6 9.8 10 10 agonist-3 0.2 2 5.2 10 14.8 18 19.6 20 a) Experiments were performed on the contraction of smooth muscleusingincreasingconcentrationsofthreeagonistsandtherespo nsesare given in Table 1. The maximum response of the system was 20mm contraction. Calculate the % maximum response of the systemforeachconcentrationofagonistandplotgraphsshowingthede pendence of the response on log [agonist]. Compare the threeagonists in terms of their maximal effect and their potency usingpharmacologicalterms. EIN 5
Ans Column I Column II Ca binds to calmodulin 1. Elastic fibers that anchor thick filanments in place Ca binds to troponin 2. Occurs in smooth muscles only Oxidative type I muscle fibers 3. Is the primary source of Ca that drives muscle contraction Titin 4. Is a dense connective tissue that surrounds the entire muscle H zone 5. Anchors thin filaments together Z line 6. Have high concentration of mitochondria Sarcomere 7. The region of thick filaments that has no overlap with thin filaments Actin and myosin 8. Is the functional unit of skeletal muscle Epimysium 9. Occurs in skeletal and cardiac muscles Sarcoplasmic reticulum 10. Generate the mechanical force of a muscle through crossbridge cycling
During cross bridge cycling in skeletal muscle, force is created by the power stroke of the: O actin filaments Otropomyosin molecules O myosin heads Otroponin molecules
Ans Column I Column II Ca binds to calmodulin 1. Elastic fibers that anchor thick filaments in place Ca binds to troponin 2. Occurs in smooth muscles only Oxidative type I muscle fibers 3. Is the primary source of Ca that drives muscle contraction Titin 4. Is a dense connective tissue that surrounds the entire muscle H zone 5. Anchors thin filaments together Z line 6. Have high concentration of mitochondria Sarcomere 7. The region of thick filaments that has no overlap with thin filaments Actin and myosin 8. Is the functional unit of skeletal muscle Epimysium 9. Occurs in skeletal and cardiac muscles Sarcoplasmic reticulum 10. Generate the mechanical force of a muscle through crossbridge cycling Matching between Column I and corresponding definition or function in column II ?
Now in your own words, EXPLAIN (1) howa neural impulse is transferred to a muscle cell this is the process of “muscle excitation"), and (2) how the electrical impulse travels into he T-tubules and causes calcium to be released from the sarcoplasmic retículum (this is the process of “excitation-contraction coupling"): OMADidoinos reticulum 5. se mo S1e hosph erah anism
Reset Hel Transverse (T- ) tubule Terminal Sarcoplasmic reticulum Sarcolemma Triad Opening of T- tubule Endomysium Muscle fiber Myofibrils Myofilaments cisternae You labeled 6 of 10 targets incorrectly 00
Put the following statements describing the skeletal muscle contration pathway in the correct order action potential enters the transverse- tubule action potential generated at motor end plate action potential travel across sarcolemma sarcoplasmic reticulum releases calcium
Follow the events of excitation-contraction coupling that lead to cross bridge activity.
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Match the folowing (with reference to skeletal muscle): iy (8] cyclcaly bnds with the T2 Tubue myosin crossbrdes T during contraction T latersisacs o (b) has ATPase actvy the sarcoplasmic(¢) supples energy for the retcuun power stroke o 4 croee 5. myosin e . troponin- (@) rapidy transmits the ac- wropomyosin tion potentia tothe complex central prtion of the 7 actin musce finer (0 ® (8) prevents actin rom in- teractng with myosin when the musce fier s el
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Which of the following proteins connects the actin filaments to the Z-band in the sarcomere? CapZ Titin Profilin Nebulin O Tropomodulin < Previous