Biochemistry: Concepts and Connections (2nd Edition)
Biochemistry: Concepts and Connections (2nd Edition)
2nd Edition
ISBN: 9780134641621
Author: Dean R. Appling, Spencer J. Anthony-Cahill, Christopher K. Mathews
Publisher: PEARSON
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Chapter 12, Problem 11P

Some anaerobic bacteria use alternative pathways for glucose catabolism that convert glucose to acetate rather than to pyruvate. Shown below is one possible metabolic pathway. The first part of this pathway (glucose to fructose-1 ,6-bisphosphate) is identical to the glycolytic pathway. In the second part of the alternative pathway, Enzymes 1—6 all have mechanisms/activities analogous to enzymes in glycolysis. Note that there are two bond C-C cleavage reactions in this new pathway.

A → B + C (Enzyme 1) and

C → B + D. All the steps where ATP is consumed or generated have been shown; however, the addition or loss of NAD+/NADH, Pi,

H2O, or has not been shown explicitly. Draw the structures for the intermediates B, F, G, H, and l, and include other reaction participants as needed.

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