Biology: Concepts and Investigations
Biology: Concepts and Investigations
5th Edition
ISBN: 9781260259049
Author: Hoefnagels
Publisher: MCG
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Chapter 16, Problem 7WIO
Summary Introduction

To analyze:

The reason why a mutation in a gene encoding a T cell coreceptor to which HIV binds might be beneficial.

Introduction:

A certain type of white platelet called a T cell plays a crucial role in the immune system and is at the core of the system known as versatile immunity, which is responsible for adjusting the body's response to specific bacteria. The T cells are like warriors who seek out and kill the targeted intruders.

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Influenza virus causes serious disease and death, and is responsible for one of the largest pandemics in recorded history.  However, the process by which antigens are made and processed are not unique to that virus. Answer the following questions to trace how infected cells will become recognizable by the TCR of a compatible T-cell. A) Where are the viral proteins made? B) Describe the process by which viral proteins are broken down into peptides. Be sure to discuss any unique molecules or organelles that participate in the process. C) Which MHC molecule presents these peptides?  D) Now that you have made peptides from the viral antigen, how do they get to and bind to the MHC molecule? Describe the process. What unique molecules are involved in this process? E) What is the final destination for these molecules/epitopes, and how do they reach that destination?
1:Describe the various stages of T cells and the events that occur during each of these stages during T cell development.  What stages of T cell development would be affected in mice with the following genetic mutations? Justify your answer. a) Mice that do not express MHC Class I molecule. b) Mice that do not express Rag1 c) Mice that do not express the pre-T-alpha chain 2:Transgenic mice that have constitutive expression of Rag1/2 are being used in an experiment to study pre-BCR signaling. Based on your knowledge of early B cell development, speculate on what might be the fate of BCR rearrangement and how will this affect further development of B cells in the bone marrow? please answer in full detail I want long well explained answers.
You are investigating a case of SCID in which you have observed that the diversity of both T- and B- cells (that is, diversity of both the TCRS and BCRS on the cells of this patient) is drastically reduced. List two genes whose mutation could produce this result, and briefly explain what each one's product normally does.

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Biology: Concepts and Investigations

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