ANATOMY+PHYSIOLOGY
4th Edition
ISBN: 9781260265217
Author: McKinley
Publisher: RENT MCG
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Chapter 27, Problem 6DYKB
Summary Introduction
Introduction:
Nutrients are the complex
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Years ago there was interest in using uncouplers such as dinitrophenol as
weight control agents. Presumably, fat could be oxidized without concomi-
tant ATP synthesis for re-formation of fat or carbohydrate. Why was this a
bad (i.e., fatal) idea?
If metabolites from fats, amino acids and lactate are to be converted to
glucose, which of the following is a common metabolic precursor?
oxaloacetate
acetyl CoA
alpha-ketoglutarate
pyruvate
succinyl CoA
Lipoic Acid is the vitamin precursor for a co-enzyme called Lipoamide
A patient diagnosed with lipoic acid deficiency exhibited fatigue and muscle cramps. The muscle cramps have been related to the accumulation of specific metabolic acids. On the following list, highlight the metabolic acids that are most likely to accumulate in a lipoic acid deficiency?
Note: There may be more than one.
Isocitrate
Pyruvate
Succinate
α-ketoglutarate
Malate
Fumarate
Briefly explain.
Chapter 27 Solutions
ANATOMY+PHYSIOLOGY
Ch. 27.1 - List the six nutrients required by the body.Ch. 27.1 - Prob. 2WDYLCh. 27.1 - Prob. 3WDYLCh. 27.2 - Prob. 4WDYLCh. 27.2 - Prob. 5WDYLCh. 27.2 - Prob. 6WDYLCh. 27.2 - Prob. 7WDYLCh. 27.2 - How may a vegetarian obtain all of the essential...Ch. 27.3 - Prob. 9WDYLCh. 27.3 - What are the major minerals? The trace minerals?...
Ch. 27.4 - What categories of food are shown on the USDA...Ch. 27.4 - What is the purpose of the requirement for...Ch. 27.5 - Prob. 13WDYLCh. 27.5 - Prob. 14WDYLCh. 27.6 - Prob. 15WDYLCh. 27.6 - Prob. 16WDYLCh. 27.6 - Prob. 17WDYLCh. 27.6 - Prob. 18WDYLCh. 27.7 - Where in the biochemical pathway of cellular...Ch. 27.7 - How is excess sugar (glucose) converted to fat...Ch. 27.8 - Prob. 21WDYLCh. 27.8 - Prob. 22WDYLCh. 27.8 - Prob. 23WDYLCh. 27 - _____ 1. Which of the following is a nutrient? a....Ch. 27 - Prob. 2DYKBCh. 27 - _____ 3. What is the major macronutrient in a...Ch. 27 - _____ 4. During the absorptive state a. blood...Ch. 27 - _____ 5. When the pancreas releases insulin, it...Ch. 27 - Prob. 6DYKBCh. 27 - _____ 7. Which of the following conditions is not...Ch. 27 - _____ 8. Total metabolic rate increases under...Ch. 27 - _____ 9. All of the following are functions of the...Ch. 27 - Prob. 10DYKBCh. 27 - Define nutrition.Ch. 27 - Prob. 12DYKBCh. 27 - Prob. 13DYKBCh. 27 - Prob. 14DYKBCh. 27 - Define minerals, and give examples of their...Ch. 27 - Define nitrogen balance, and compare positive...Ch. 27 - Define the postabsorptive state. What is the major...Ch. 27 - Explain the function of the liver in the transport...Ch. 27 - Prob. 19DYKBCh. 27 - Prob. 20DYKBCh. 27 - An individual has recently adopted a vegetarian...Ch. 27 - Prob. 2CALCh. 27 - Prob. 3CALCh. 27 - Prob. 4CALCh. 27 - Prob. 5CALCh. 27 - Prob. 1CSLCh. 27 - Prob. 2CSLCh. 27 - Prob. 3CSL
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- The energy for the production of ATP comes from the breakdown of a glucose molecule via many enzyme-mediated chemical reactions occurring at several distinct stages of cellular respiration. During this time, the chemical energy stored in glucose is continually trans- ferred across these reactions. Which of the following describes the form in which most of the energy from the glucose molecule is stored just before the oxidative phosphorylation stage in aerobic cellular respiration? A B с D acetyl CoA FADH 2 NADH pyruvatearrow_forwardThiamine is the vitamin precursor for a co-enzyme called thiamine pyrophosphate or TPP. A patient diagnosed with thiamine deficiency exhibited fatigue and muscle cramps. The muscle cramps have been related to the accumulation of specific metabolic acids. On the following list, circle the metabolic acids that are most likely to accumulate in a thiamine deficiency? Note: There may be more than one. Isocitrate Pyruvate Succinate α-ketoglutarate Malate Fumarate (b) Provide a brief explanation for your answer to 1 (a) herearrow_forwardWhich of the following cellular concentrations would be likely to increase the rate of glycolysis? Low AMP levels High glucagon levels ✓Low fructose-2,6-bisphosphate levels High AMP levels High phosphoenolpyruvate levels Low ATP levelsarrow_forward
- What are two important compounds that lie at crossroads of major metabolic pathways? Select both that apply. Glucose Pyruvate Glycerol 3-Phosphoglycerate Alanine Acetyl CoAarrow_forwardTrue False Glucose oxidase can be used in determining glucose in the blood and urine Regardless of the distance between the enzyme and substrate, they will bind. Lipase is an enzyme primarily produced by the pancreas that breakdown peptide bonds between the oxygen molecules of glycerol and the hydroxyl molecules of fatty acids. Coenzymes are organic substances, while cofactors are inorganic. L-Amino-acid oxidase will catalyze reactions of D (-) - glycine. Redox reaction via oxidoreductase is still possible with one reactant only. The apoenzyme is the protein part of the enzyme, which is enzymatically inactive without cofactors. Lack of enzymes will lead to block in metabolic pathways causing inborn errors of metabolism Ligases are enzymes that catalyze the breakdown of chemical bonds. Ribozymes are catalytically active RNA molecules or RNA-protein complexesarrow_forwardYears ago there was interest in using uncouplers such as dinitrophenol asweight control agents. Presumably, fat could be oxidized without concomitant ATP synthesis for re-formation of fat or carbohydrate. Why was this a bad (i.e., fatal) idea?arrow_forward
- The complete oxidation of glucose 6-phosphate derived from free glucose yields 30 molecules ATP, whereas the complete oxidation of glucose 6- phosphate derived from glycogen yields 31 molecules of ATP. Account for this difference.arrow_forwardPhosphofructokinase (PFK-1) is one of the most regulated enzymes in metabolism. Based on all of the principles we have learned in this class, which of the following would be most likely to be an allosteric activator of PFK-1? a Pyruvate b Acetyl CoA c Citric acid d glucosearrow_forwardFructose is a labeled on its anomeric carbon with 14C. This labeled fructose is added to muscle cells under anaerobic glycolytic conditions, and the secreted lactate is collected. Which carbon in the secreted lactate (shown below) contains the 14C label? دیده OH Carbon 2 Carbon 1 Carbon 3 No carbon contains the label.arrow_forward
- Why does the lack of glucose 6-phosphatase activity in the brain and muscle make good physiological sense? Glucose 6-phosphatase allows cells to trap glucose in the cell; however, these tissues primarily rely on noncarbohydrate energy sources. Glucose 6-phosphatase allows cells to generate glucose through gluconeogenesis; however, gluconeogenesis only takes place in the liver. Glucose 6-phosphatase allows cells to release glucose into the blood; however, these tissues should never release glucose. Glucose 6-phosphatase provides glucose 6-phosphate for glycogen synthesis; however, these tissues do not need glycogen.arrow_forwardTPI deficiency is a rare human condition. Patients who lack TPI cannot convert the triose dihydroxyacetone phosphate into glyceraldehyde 3-phosphate.What happens to glycolysis in TPI patients?TPI patients suffer from chronic hemolytic anemia (abnormal breakdown of red blood cells) and have variable neuromuscular dysfunctions, including muscle weakness, poor muscle tone, and atrophy. Most die of respiratory failure during childhood. Explain why TPI-deficient patients exhibit these conditions using the diagram to justify your answer. TPI is enzyme 5.G6PD deficiency is one of the most common human genetic conditions, affecting about 40 million people worldwide. Patients suffer from hemolytic anemia when exposed to certain drugs, viral or bacterial disease, or fava beans.arrow_forwardWhich metabolic pathway do you conclude the supplement selenium to most directly affect or interact with? This could be any pathway in primary metabolism, proteolysis, lipolysis or other catabolic pathway associated with metabolic activity. Be specific with the pathway please and thank you!arrow_forward
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