CH,0 CH2O donepezil CH30 CH;0

Q: Он о OH O Он о Он о H. ÓH II IV V Which of the following molecules is not a possible product when a…

A: Aldol condensation: The alpha hydrogen of carbonyl compounds is acidic in nature and it is removed…

Q: H H H CHCНО, 20° Cinnamaldehyde нн OH CH:COCH3, 100° -CH3 Crossed aldol condensations Benzaldehyde…

A: Three products based on crossed aldol condensation with benzaldehyde, whose mechanism is to be…

Q: Draw the missing products or reagents in the following multistep synthesis. Ignore any inorganic…

A: The reactions involves free radical halogenation of cyclopentane and then it's reaction with NaOH to…

Q: Reaction benzaldehyde with (CH3CN) in presence of base called ? (a)Dopner reaction (b)Crossed…

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Q: Enolate Chemistry PS 2: Aldol Reactions B H. D Ph. H. Ph. H.

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Q: Help

A: In aldol condensation, the base abstract the proton from the alpha carbon, the enolate carbon then…

Q: Q/ Give the product for the following reactions: OH (1)Acetone + acetaldehyde OH (2)2 Acetone ? Q/…

A: The reaction which is occur between the enolate ion and the carbonyl compound is known as aldol…

Q: 1. NaOEt 2. H2SO4 / heat Which compound is the correct product for the intramolecular Aldol reaction…

A: In the given compound two carbonyl groups present in the same compound. Hence when this compound…

Q: 4. Give the structures of two compounds that can react together to form the following compound by a…

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Q: Use the retro synthesis to determine the diketone from which the following compounds were formed by…

A: In the intramolecular alodol condenstation reaction nucleophilic attack happen in the same molecule.

Q: Draw the product of the following directed aldol reaction. CH3. [1] LDA, THE [2] CH,CHO [3] H20…

A: The abbreviation of an aldehyde and alcohol is called an aldol reaction. In this process, the base…

Q: Would the following reaction form the product as shown? (CH3CH₂)2NH H A) Yes, it is easier to form…

A: Would the following reaction form the product shown? = A) Yes, it is easier to form the diketone…

Q: What conditions are necessary for a crossed-aldol reaction to occur? NaOH, H20 H. H. 50° C I II O…

A: In this question, we have to find out the correct answer of given problem by the help of the…

Q: 3. Robison annulation involves a Michael addition followed by aldol condensation. The reaction is…

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Q: Vanillin can be reacted with a number of ketones to give interesting aldol condensation products.…

A: option- D is correct

Q: 2) Increasing yield in cross Aldol condensation p-methyl benzaldehyde, p-methoxy benzaldehyde,…

A: Aldol condensation is the condensation of two distinct aldehydes or ketones, at least one of which…

Q: 4. Give the crossed aldol product for the following reaction. NaOH (aq) + H. 25 °C

A: The Cross Aldol condensation reaction is a type of organic reaction . In the Reaction two Carbonyl…

Q: Draw the product formed from an aldol reaction with the given starting material(s) using OH, H,C. a.…

A: The carbanion formed by the abstraction of proton by the OH- ions on the 2-methyl propanal, is less…

Q: Propose a mechanism, using curved arrows, for the base-catalysed aldol reaction and the subsequent…

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Q: 3-Methylbutanal undergoes an aldol reaction to form 3-hydroxy-2-isopropyl-5-methylhexanal 10% NaOH…

A: In the aldol reaction, the formation of beta-hydroxyl aldehyde/ketone product takes place by the…

Q: Give a mechanism for the preparation of the appropriate benzalacetophenone using the aldehyde…

A: When acetophenone reacts with p-anisaldehyde in presence of NaOH followed by heating then…

Q: How would you prepare the following compound using either an acetoacetic ester synthesis or a…

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Q: 17. Which of the following are intermediates in the acid catalyzed aldol reaction of propanal to…

A: Aldol reaction can occur in both basis and acidic medium

Q: 5. Which of the following compounds will not undergo Aldol reaction and why? `H `H а. b. CH3 с. d.…

A: If adjacent carbon of carbonyl carbon contain alpha hydrogen (sp3 hybridised) then undergo aldol…

Q: 4. What is the intermediate of the following reaction sequence? 1. O3 Proline ? 2. (CH3)2S (Aldol…

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Q: 25°C HO. HO. Na* OH (aq) OH (aq) 25°C 85°C aldol

A: Answer:- This question is answered by using the simple concept of chemical reaction of self Claisen…

Q: What is TRUE about the reaction below? Select one: O a. The reaction has the same rate when the base…

A: Organic reactions are those in which organic reactant react to form organic products.

Q: There are other condensation reactions similar to the aldol and Claisen condensations: a. The Perkin…

A: The Perkin condensation is the condensation of an aromatic aldehyde and acetic anhydride. It is…

Q: Determine the product and name of the rxn HO 1. Аc-0, AcO-Na+ (A) 2. Н20 Ac20= acetic anhydride…

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Q: OH base + H20 heat H3C H. The aldol reaction is a carbonyl condensation reaction between two…

A: The beta-hydroxy aldehyde gives an E1cB elimination reaction to give an alkene. The first step of…

Q: One step in a recent short synthesis of a prostaglandin involves the conversion of succinaldehyde to…

A: The mechanism is as follows,

Q: Cinnamaldehyde may be synthesized through aldol condensation reaction of two aldehydes Q and R as…

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Q: What is the first step in a base catalyzed aldol reaction?   A. Protonation of Carbonyl group…

A: There are two main steps in an aldol condensation Reaction -  (1) Formation of enolate by Reaction…

Q: Robinson Annulation Practice Problems: Fill in the missing intermediates, products or starting…

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Q: Draw the step-by-step mechanisms for the following reactions: a) Step 1 of the aldol condensation OH…

A: In an aldol condensation reaction product formed β- hydroxy carbonyl compound then elimination shows…

Q: OH OH Ni 25°C heat E2 H, H. aldol 1) LIAIH, 2) H,O*

A: In aldol condensation reaction, two carbonyl compounds (aldehydes or ketones) react with each other…

Q: 1. Show the method to carry out each transformation: two-step method using a Grignard reagent. CH3…

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Q: Draw the structure of the major aldol product (prior to possible dehydration) of the following…

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Q: Which of the following molecules is not able to undergo an aldol self-condensation? CH₂ A H₂C 00.0 어…

A: we have to select the molecule which cannot participate in aldol self condensation

Q: Which of the following compounds would you expect to undergo aldol self- condensation? Show the…

A: A condensation reaction is that in which two mole of the same molecule are condensed.

Q: Draw the product formed in each directed aldol reaction.

A: Aldol Condensation Reaction: The carbonyl compound having Alpha-hydrogen in the presence of base…

Q: Which compounds below were reacted to give the dehydrated Aldol product shown? NaOEL, EIOH 80 °C

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Q: What is the structural requirement of the following reactions? 1) Iodoform Reaction 2) Aldol…

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Q: the resulting aldol from the following? OH 2

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Q: What carbonyl starting materials are needed to prepare each compound using a directed aldol…

A: For aldol reaction, aldehyde and ketones must have atleast one alpha hydrogen atom when treated with…

Q: 4-methyl,2-pentanol by aldol comdensation with mechanisam

A: Aldol condensation is a base catalyzed condensation reaction in which two molecules of carbonyl…

Q: Propose a correct retrosynthetic analysis of (E)-1,3-di(furan-2-yl)prop-2-en-1-one following an…

A: Aldol condensation :  Alpha H containing carbonyl compounds in presence of dil. base gives beta…

Q: What product is obtained from the aldol condensation of cyclohexanone?

A: Aldol condensation of the ketones having α-hydrogen undergo condensation in the presence of a base…

Q: What aldehyde or ketone is needed to prepare each compound by an aldol reaction?

A: To find: The aldehyde or ketone which is needed to prepare the given compound using aldol reaction

Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.