Kindly refer to the image and answer the question 5. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action
Kindly refer to the image and answer the question 5. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of action
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter9: Cell Communication
Section: Chapter Questions
Problem 12RQ: Histamine binds to the H1 G-protein-linked receptor to initiate the itchiness and airway...
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Question
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Kindly refer to the image and answer the question
5. Cite a
and explain its mechanism of action
![1 Unoccupied receptor does
not interact with G, protein.
Extra-
collular
space
-Hormone or neuro-
transmitter
Cell
membrane
Gs protein
with bound GDP
Synaptic signaling
Receptor
Target
cell
Inactive adenylyl
Cytosol
GOP
cyclase
Nerve
cell
Occupied receptor changes
2 shape and interacts with a
subunit of G, protein. G, protein
releases GDP and binds GTP.
Neurotransmitter
Endocrine signaling
Hormone
Inactive
adenylyl
cyclase
GTP
Target
cell
GDP
a Subunit of G, protein
3 dissociates from By and
Blood vessel
activates adenylyl cyclase.
Active
adenylyl
cyclase
Direct contact
АТР
Gap
junction
GTP
CAMP + PP
When hormone is no longer
4 present, the receptor reverts
to resting state. GTP on the
a subunít is hydrolyzed to GDP,
a rejoins By, and adenylyl
cyclase is deactivated.
Signaling
cell
Target
cells
Inactive
adenylyl
cyclase](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F2e0e719c-f39d-4817-a05d-0db117e2e885%2F8b1a7e76-1ffb-46e5-9705-6aef04ec0047%2F4zxfkpn_processed.png&w=3840&q=75)
Transcribed Image Text:1 Unoccupied receptor does
not interact with G, protein.
Extra-
collular
space
-Hormone or neuro-
transmitter
Cell
membrane
Gs protein
with bound GDP
Synaptic signaling
Receptor
Target
cell
Inactive adenylyl
Cytosol
GOP
cyclase
Nerve
cell
Occupied receptor changes
2 shape and interacts with a
subunit of G, protein. G, protein
releases GDP and binds GTP.
Neurotransmitter
Endocrine signaling
Hormone
Inactive
adenylyl
cyclase
GTP
Target
cell
GDP
a Subunit of G, protein
3 dissociates from By and
Blood vessel
activates adenylyl cyclase.
Active
adenylyl
cyclase
Direct contact
АТР
Gap
junction
GTP
CAMP + PP
When hormone is no longer
4 present, the receptor reverts
to resting state. GTP on the
a subunít is hydrolyzed to GDP,
a rejoins By, and adenylyl
cyclase is deactivated.
Signaling
cell
Target
cells
Inactive
adenylyl
cyclase
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