Biology 2e
2nd Edition
ISBN: 9781947172517
Author: Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher: OpenStax
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Chapter 10, Problem 32CTQ
Chemotherapy drugs such as vincristine (derived from Madagascar periwinkle plants) and colchicine (derived from autumn crocus plants) disrupt mitosis by binding to tubulin (the subunit of microtubules) and interfering with microtubule assembly and disassembly. Exactly what mitotic structure is targeted by these drugs and what effect would that have on cell division?
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In the following study, the investigators wanted to determine the role of cyclin B
in controlling the cell cycle. Earlier researchers had found that extracts made
from frog eggs (Xenopus) contained all the necessary proteins and machinery
required for DNA replication. This included proteins that regulated the mitosis
promoting factor (MPF). At the time of this study, cyclin B was show to affect MPF
activity and the research group wanted to test using Xenopus egg extract in an
assay. In Figure 1 (a) MPF activity was tested for its ability to phosphorylate
Histone (H1) in sperm chromatin over a certain period of time. Additionally, the
cyclin B concentration in the extract was measured.
In figure 1b, the extract was tested after treatment with RNase which degraded
only the mRNA and not RNA or FRNA in the extract. Knowing that cyclin B is a
short-lived protein, why do you suppose the graph shows the results you see in
figure 1b?
1) Examine the picture of an onion root tip with cells in various stages of the cell cycle. A student claims that interphase is the longest stage of the cell cycle. Another student claims that mitosis is the longest stage. Using evidence from the photo, determine which student is correct and why.
A) Mitosis is the longest stage because anaphase requires more time to separate chromatids.
B) Interphase is the longest stage because chromosomes are visible in the majority of the cells.
C) Mitosis is the longest stage because the majority of the cells in the photo are replicating their DNA.
D) Interphase is the longest stage because the majority of the cells in the photo have uncondensed chromatin and are not dividing.
Not Graded
The anticancer drug paclitaxel (Taxol), derived from the Pacific Yew, has many effects on mitosis. One of its most powerful effects is that it prevents disassembly of the mitotic spindle, which prevents spindle fibers from shortening. Which phase of mitosis would this directly affect? Why would this stop cell division overall and lead to cell death?
Chapter 10 Solutions
Biology 2e
Ch. 10 - Figure 10.6 Which of the following is the correct...Ch. 10 - Figure 10.13 Rb and other proteins that negatively...Ch. 10 - Figure 10.14 Human papillomavirus can cause...Ch. 10 - A diploid cell has ________ the number of...Ch. 10 - An organism s traits are determined by the...Ch. 10 - The first level of DNA organization in a...Ch. 10 - Identical copies of chromatin held together by...Ch. 10 - S. Chromosomes are duplicated during what stage of...Ch. 10 - Which of the following events does not occur...Ch. 10 - The mitotic spindles arise from which cell...
Ch. 10 - Attachment of the mitotic spindle fibers to the...Ch. 10 - Unpacking of chromosomes and the formation of a...Ch. 10 - Separation of the sister chromatids is a...Ch. 10 - The chromosomes become visible under a light...Ch. 10 - The fusing of Golgi vesicles at the metaplhase...Ch. 10 - At which of the cell-cycle checkpoints do external...Ch. 10 - What is the main prerequisite for clearance at the...Ch. 10 - If the M checkpoint is not cleared, what stage of...Ch. 10 - Which protein is a positive regulator that...Ch. 10 - Many of the negative regulator proteins of the...Ch. 10 - Which negative regulatory molecule can trigger...Ch. 10 - are changes to the order of nucleotides in a...Ch. 10 - A gene that codes for a positive cell-cycle...Ch. 10 - A mutated gene that codes for an altered version...Ch. 10 - Which molecule is a Cdk inhibitor that is...Ch. 10 - Which eukaryotic cell-cycle event is missing in...Ch. 10 - FtsZ proteins direct the formation of a...Ch. 10 - Compare and contrast a human somatic cell to a...Ch. 10 - What is the relationship between a genome,...Ch. 10 - Eukaryotic chromosomes are thousands of times...Ch. 10 - Briefly describe the events that occur in each...Ch. 10 - Chemotherapy drugs such as vincristine (derived...Ch. 10 - Describe the similarities and differences between...Ch. 10 - List some reasons why a cell that has just...Ch. 10 - What cell-cycle events will be affected in a cell...Ch. 10 - Describe the general conditions that must be met...Ch. 10 - Compare and contrast the roles of the positive...Ch. 10 - What steps are necessary for Cdk to become fully...Ch. 10 - Rb is a negative regulator that blocks the cell...Ch. 10 - Outline the steps that lead to a cell becoming...Ch. 10 - Explain the difference between a proto-oncogene...Ch. 10 - List the regulatory mechanisms that might be lost...Ch. 10 - ______ can trigger apoptosis if certain cell-cycle...Ch. 10 - Name the common components of eukaryotic cell...Ch. 10 - Describe how the duplicated bacterial chromosomes...
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- 3) Examine the graph showing the relative percentage normal and cancer cells spend in various stages of the cell cycle. Based on the information in the graphs, infer how cancer cells differ from typical, noncancerous cells. Select ALL that apply. A) Cancer cells do not replicate their DNA. B) Cancer cells replicate their DNA too quickly. C) Cancer cells do not go through interphase during their cell cycle. D) Cancer cells spend more time dividing compared to typical cells. E) Cancer cells do not always grow to the same size as typical cells. more than 1 answer. not gradedarrow_forwardDiscuss the complete cell cycle in a human cell, mitosis and meiosis, and the regulatory components (i.e. the proteins associated with cellular checkpoints) of the cell cycle. Tumor growth results when the cell cycle checkpoints are ignored. Give an example of how tumor growth could result from either a loss-of-function or a gain-of-function mutation.arrow_forwardBelgy Name: Date: Period: Mitosis Worksheet The diagram below shows six cells in various phases of the cell cycle. Note the cells are not arranged in the order in which mitosis occurs and one of the phases of mitosis occurs twice. Use the diagram to answer questions 1-7. Phases of the Cell Cycle 1) Cells A and early stage of the same phase of mitosis. What phase is it? 2) Which cell is in mg 3) Which cell rst phas sis? 4) In cell A, what structure is labeled X? 5) Which cell is in the "in between" phase of mitosis? 6) Place the diagrams in order from first to last. 7) Are the cells depicted plant animal cells? Explain your answer. 8) What is the longest phase of the cell cycle? 9) Why is mitosis important?arrow_forward
- 1) What phase of mitosis is this? Answer: 2) What is the indicated structure 1? select one. a. chromosome b. chromosome with two sister chromatids c. centrioles/centrosome d. spindle fibres e. metaphase plate 3)If the diploid (2n) number of this cell is 8 how many chromosomes are present? 4) If the diploid (2n) number of this cell is 8 how many sister chromatids are present? 5) If the diploid (2n) number of this cell is 8 how many homologous pairs are present?arrow_forwardPart A and B A. What below would be likely to lead to cancer development? A) Overexpression of a cell cycle checkpoint inhibitor B) Loss of expression of a growth factor that promotes cell cycle entry C) Overexpression of a receptor tyrosine kinase that promotes cell cycle entry D) Overexpression of a DNA damage repair enzyme E) Loss of expression of a regulatory transcription factor that activates transcription of a cyclin B. Taxols inhibit the proper function of microtubules and are frequently used as chemotherapy drugs. What is the function of microtubules during the cell cycle? A) They promote the G1 to S checkpoint B) They normally inhibit M phase from being completed C) They form the mitotic spindle E) They mediate DNA replication F) They form the cleavage furrow during cytokinesisarrow_forwardExplain why we can say that M-phase of the cell-cycle is triggered by a positive feedback loop. a) What would the consequences be if cohesins were working normally but condensins were not? and b) what stage of the cell cycle would this cause problems in? Why is it important for the centrosome to duplicate during G1-G2 (interphase) before M phase? The kinetochores serve as a link between the sister chromatids and the microtubules attached to the mitotic spindle. a) How are microtubules still able to exhibit dynamic instability after they are bound to the sister chromatids and b) why is this important to mitosis? As the name suggests, the Anaphase-promoting-complex (APC), promotes the 4th phase of mitosis by separating the sister chromatids so they can travel to separate poles of the cell, and prevents them from being re-zipped together. Describe how APC does these two things (Hint: one involves M-cyclin and the other involves…arrow_forward
- In order to investigate the cell cycle in HEK293 cells in culture, I ran a flow cytometry experiment. I labeled their nuclei with DAPI to analyze DNA content. In these flow cytometry plots below, label the two main phases of the cell cycle that you can see. Briefly, explain your answer.arrow_forwardDescribe the likely consequences of bypassing the G1 and G2 checkpoints in the cell cycle. Why do compounds like nonylphenol lead to the multiplication of abnormal cells?arrow_forwardThe cell cycle control system is a cycling set of molecules in the cell that triggers and coordinates key events in the cell cycle. This is all controlled by growth factors. a) Identify the major checkpoints in a cell and its function. b)Explain the role of the growth factor.arrow_forward
- 0200 7 The anticancer drug paclitaxel (Taxol), derived from the Pacific Yew, has many effects on mitosis. One of its most powerful effects is that it prevents disassembly of the mitotic spindle, which prevents spindle fibers from shortening. Which phase of mitosis would this directly affect? Why would this stop cell division overall and lead to cell death? LANDY సిగోలుకుం చగన 40 92800arrow_forwardReview the events associated with each stage of mitosis in addition to the preparatory stage, interphase. List these events in table. Some events and structures occur only in plant cells and some occur only in animal cells. Mark these events in your list with an asterisk. This list can serve as an excellent study guide, so be as complete as possible. Interphase Prophase Prometaphase Metaphase Anaphase Telophasearrow_forwardYou are studying the effect of a M-phase cyclin B mutant on mitosis,. This protein has its lysines mutated to alanines such that it can not undergo ubiquitination Which of the following would occur? Select all that apply This mutant M-phase cyclin B will not be degraded in the proteosome The cell expressing this mutant M-phase cyclin B will stall in mitosis The cell expressing this mutant M-phase cyclin B will complete mitosis The cell expressing this mutant M-phase cyclin B will not exit mitosisarrow_forward
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Cell Division - Mitosis and Meiosis - GCSE Biology (9-1); Author: Mr Exham Biology;https://www.youtube.com/watch?v=w7vp_uRA8kw;License: Standard YouTube License, CC-BY