Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 15.3, Problem 2R
Summary Introduction
To review:
The process by which a gene mutation is mapped and detected before knowing its protein product.
Introduction:
The process in which sudden heritable changes (either in structure or in content) in genotype occurs, is called a mutation. These mutations, most of the time, lead to many diseases. To identify the disease, deoxyribonucleic acid (DNA) markers are used for linkage analysis.
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What are disease-causative mutations?
Which best describes genetic mutations?
A) Genetic mutations that cause diseases are always passed on to offspring.
B) Some inherited genetic mutations can be good for the offspring.
C) Different genetic mutations cause few forms of cancer.
D) Somatic mutations can be inherited from parents or acquired during life.
What is adenomatous polyposis coli (APC) gene ? How it works ?
Chapter 15 Solutions
Life: The Science of Biology
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- While a stem cell transplant from an unaffected donor is currently the only cure for DBA, genome-editing technologies may one day enable the correction of a mutation in a patient’s own bone marrow stem cells. However, what specific information would be needed, beyond a symptom-based diagnosis of DBA, in order to accomplish this?arrow_forwardGene mutations can be classified in two major ways:(1) hereditary or germline mutations that are inherited from a parent and are present throughout a person’s life in virtually every cell in the body.(2) acquired or somatic mutations that occur at some time during a person’s life and are present only in certain cells, not in every cell in the body.If there is no family history of a particular disease but a child has the disease then it may have arisen due to a(n) ________ mutation early during development. A) acquired B) inherited C) silent D) transitionarrow_forwardWhat is gene knockout ?arrow_forward
- what is another type of disease caused by a duplication mutation? How does it present itself?arrow_forwardThe nurse is explaining the general goal of gene therapy to a patient. With gene therapy, the general goal is to transfer exogenous genes to a patient for which result? a )To change the patient’s own genetic functioning to treat a given disease b )To improve drug metabolism c )To prevent genetic disorders in the patient’s future children d )To stimulate the growth of stem cellsarrow_forwardWhich of the following is an enabling characteristic for cancer that can increase the likelihood of both passenger and driver mutations? a) Increased angiogenesis O b) Tumor-promoting inflammation O c) Avoiding immune destruction O d) Genome instability acerarrow_forward
- Define gene knockout.arrow_forwardDescribe and give examples of direct reversal of DNA damage.arrow_forward1) A mutation is a change that occurs in our DNA sequence, either due to mistakes when the DNA is copied or as the result of environmental factors. All BUT ONE of the statements below correctly describes or explains genetic mutations. A) Mutation can disrupt normal cell activity and cause diseases, like cancer. B) Mutations in parents' cells are then passed down to offspring via reproduction. C) Our cells can recognise any potentially mutation-causing damage and repair it before it permanent. D) Mutations can occur as the result of exposure to environmental factors such as smoking, toxins and radiation.arrow_forward
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