Concepts of Biology
1st Edition
ISBN: 9781938168116
Author: Samantha Fowler, Rebecca Roush, James Wise
Publisher: OpenStax College
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Chapter 17, Problem 3ACQ
Figure 17.17 The Rh antigen is found on Rh-positive red blood cells. An Rh-negative female can usually carry an Rh-positive fetus to term without difficulty. However, if she has a second Rh-positive fetus, her body may launch an immune attack that causes hemolytic disease of the newborn. Why do you think hemolytic disease is only a problem during the second or subsequent pregnancies?
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Figure 17.17 The Rh antigen is found on Rh-positive red blood cells. An Rh-negative female can usually carry an Rh-positive fetus to term without difficulty. However, if she has a second Rh-positive fetus, her body may launch an immune attack that causes hemolytic disease of the newborn. Why do you think hemolytic disease is only a problem during the second or subsequent pregnancies?
When a mother is Rh-, there is a chance the baby may have hemolytic disease of Newborns. Rh+
mothers do not have this issue.
Why? Rh- moms do not have the Rh antigen in their body. A Rh- mom can have a Rh+ baby
depending on the male sperm. During pregnancy, Rh- mom can be exposed to her baby's Rh
antigen.
Let's look at figure a) the first pregnancy. The Rh- mom is pregnant with a Rh+ baby. The baby
exposes the mom to Rh antigen during pregnancy. This first baby is delivered and is ok.
Figure (b) between pregnancies, the mother is exposed to the foreign antigen Rh and she makes
antibodies against Rh. She now has anti-D (anti-Rh) in her body.
Figure (c) her second pregnancy with a Rh+ baby. On the next pregnancy that the mom has with a
baby. The mom has the anti-D (anti-Rh) antibody in her system. The antibody will attack the
baby's RBCS with the Rh antigen on it.
When the baby's RBC's are attacked the RBC will hemolyse (hemo=RBC; Lysis=cut). This will
result in severe anemia. The lysed…
The Rh antigen is found on Rh-positive red blood cells. An Rh-negative female can usually carry an Rh-positive fetus to term without difficulty. However, if she has a second Rh-positive fetus, her body may launch an immune attack that causes hemolytic disease of the newborn. Why do you think hemolytic disease is only a problem during the second or subsequent pregnancies?
Chapter 17 Solutions
Concepts of Biology
Ch. 17 - Figure 17.5 Which of the following statements...Ch. 17 - Figure 17.6 Influenza virus is packaged in a viral...Ch. 17 - Figure 17.17 The Rh antigen is found on...Ch. 17 - Which statement is true? a. A virion contains DNA...Ch. 17 - The viral ________ plays a role in attaching a...Ch. 17 - Which statement is true of viral replication? a....Ch. 17 - Which of the following is a barrier against...Ch. 17 - Although interferons have several effects, they...Ch. 17 - Which innate immune system component uses MHC...Ch. 17 - The humoral immune response depends on which...
Ch. 17 - The fact that the body does not normally mount an...Ch. 17 - Foreign particles circulating in the blood are...Ch. 17 - Allergy to pollen is classified as _______. a. an...Ch. 17 - A potential cause of acquired autoimmunity is...Ch. 17 - Autoantibodies are probably involved in ________....Ch. 17 - Why can’t dogs catch the measles?Ch. 17 - Why is immunization after being bitten by a rabid...Ch. 17 - Different MHC class I molecules between donor and...Ch. 17 - If a series of genetic mutations prevented some,...Ch. 17 - How do B and T cells differ with respect to...Ch. 17 - Why is the immune response after reinfection much...Ch. 17 - Some photographers develop a sensitivity to...
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- Figure 42.16 The Rh antigen is found on Rh positive red blood cells. An Rh-negative female can usually carry an Rh-positive fetus to term without difficulty. However, if she has a second Rh-positive fetus, her body may launch an immune attack that causes hemolytic disease of the newborn. Why do you think hemolytic disease is only a problem during the second or subsequent pregnancies?arrow_forwardWhich of the following statements is NOT correct about the immunological incompatibility between mother and baby? Select one: a. The baby’s Rh+ blood will never get in contact with the mother’s Rh– blood during the pregnancy as the placenta does not allow fetal blood cells to mix with the maternal blood. b. When the mother has Rh– blood, anti-Rh antibody injection is given during her pregnancy to prevent any antibodies from forming. c. If the baby is Rh+ and the mother is Rh–, it does not pose a problem as long as this is the mother’s first pregnancy. d. Rh– blood has no rhesus factor proteins and therefore will produce antibodies for the Rh factor when exposed to Rh+ blood.arrow_forwardthe disease erythroblastosis fetalis develops in a fetus or a newborn infant with rh-positive blood and an rh-negative mother. symptoms result when maternal anti-rh antibodies cross the placenta and interact with the fetus' erythrocytes. what are the children of rh-positive mothers not at risk for this disease? why are rh-negative fetuses not at risk for this disease?arrow_forward
- For the following mechanism that is thought to contribute to maternal–fetal tolerance, state whether you would consider it to be an example of T cell tolerization, control of responses by regulatory lymphocytes, immune deviation or immune privilege: a) Tissues at the maternal–fetal interface are populated with non-professional APCs that lack costimulatory moleculesarrow_forwardAn Rh- mother is given Rh immune globulin during her pregnancy. Rh immune globulin prevents formation of antibodies to Rh antigens. Explain why this is done.arrow_forwardYou find your vegan neighbor with her one-year-old daughter at the hospital where you are training as a medical student. She tells you that her daughter is not doing well after switching from breast milk to a solid diet, and has started to grow pale and is sleeping all the time. You find that her height and weight are way below normal. A blood test reveals the hyper segmentation of neutrophil cells, an indicator of bone marrow malfunction. You deduce that she has pernicious anemia, and refer her to an experienced doctor. Explain the development of anemia in this case, and propose a long term treatmentarrow_forward
- For the following mechanism that is thought to contribute to maternal–fetal tolerance, state whether you would consider it to be an example of T cell tolerization, control of responses by regulatory lymphocytes, immune deviation or immune privilege: a) Placental cells express FasL and can kill Fas-expressing maternal T cells.arrow_forwardYou have a patient with prostate cancer. The cancer causes blood vessels to weaken and burst. The patient has a dangerously low Hematocrit and needs a blood transfusion. When you test his blood for type, here are the results: Anti-A- agglutination, Anti-B- agglutination, Anti-Rh- no reaction. 1. List all blood types he can receive. When you enthusiastically suggest that blood transfusions will help him, he protests that his religious beliefs disallow him from accepting transfusions. You will need to find a way to help his own body both retain the blood he has, and make new blood. 2. Based only on what we've learned so far re: blood and endocrine, come up with hypotheses about how you could do each. 3. Propose a mechanism of how EPO might work: what cells might it target, would it enter them, and what sorts of proteins might it activate? (This question references endocrine: how hormones work, and why it matters if they are water-soluble or fat-solube) 4. There is a drug called…arrow_forwardWhy is it that Rh incompatibility can be a serious problem when anRh-negative mother is carrying an Rh-positive fetus, but ABOincompatibility between mother and fetus is usually no problem?That is, a type A mother can usually safely carry a type B fetus.(Hint: The antibodies produced by an Rh-negative mother againstthe Rh antigen are usually IgG, whereas the antibodies producedagainst the A or B antigens are IgM.) Because the Rh antigenobviously serves no vital function (most humans lack it), why do youthink it hasn’t been completely eliminated during human evolution?arrow_forward
- Even though instances of fetal, maternal ABO, incompatibility are common, severe hemolytic disease due to ABO incompatibility is rare. Which of the following best explains this difference? A) ABO incompatibility causes extensive extra medullary hematopoiesis B) antibodies against ABO antigens do not bind complement C) the maternal immune system is tolerant to ABO ANTIGENS D) most anti- A or anti- B antibodies are of IgM type and do not cross the placenta E) the presence of concurrent Rh incompatibility decreases the immunogenicity of erythrocytesarrow_forwardA woman who is Rh- mates with a man who is Rh+. Since the Rh+ is dominant, what would the fetus's Rh factor type be?A person who is Rh- can donate blood to other people who are either Rh+ or Rh-. However, an Rh+ person can only give blood to who? Please explain.arrow_forwardMyoglobin levels are higher in Tibetans and other ethnic groups that live at high altitudes. Explain the benefit of higher myoglobin levels for individuals living at high altitudes. An Rh- mother is given Rh immune globulin during her pregnancy. Rh immune globulin prevents formation of antibodies to Rh antigens. Explain why this is done.arrow_forward
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