(a)
Interpretation:
The complete, detailed mechanism and the major organic product for the given reaction is to be drawn.
Concept introduction:
When
Answer to Problem 18.68P
The complete, detailed mechanism and the major organic product for the given reaction is as shown below:
Explanation of Solution
The given reaction is as shown below:
The given reaction is a crossed aldol condensation as the nucleophilic species is generated from a different ketone than the one that is attacked. Firstly, the given ketone is treated with LDA to produce
The complete, detailed mechanism and the major organic product for the given reaction is as shown below:
The complete, detailed mechanism and the major organic product for given reaction is drawn by crossed aldol reaction followed by dehydration of
(b)
Interpretation:
The complete, detailed mechanism and the major organic product for given reaction is to be drawn.
Concept introduction:
When ketone is treated with sodium hydroxide, the product
Answer to Problem 18.68P
The complete, detailed mechanism and the major organic product for given reaction is as shown below:
Explanation of Solution
The given reaction is as shown below:
The given reaction is a crossed aldol reaction. In Step 1,
The complete, detailed mechanism and the major organic product for given reaction is drawn on the basis of crossed aldol reaction mechanism.
(c)
Interpretation:
The complete, detailed mechanism and the major organic product for given reaction is to be drawn.
Concept introduction:
When aldehyde is treated with sodium hydroxide, the product
Answer to Problem 18.68P
The complete, detailed mechanism and the major organic product for given reaction is as shown below:
Explanation of Solution
The given reaction is
The given reaction is intramolecular aldol condensation reaction as the sodium hydroxide and heat is given. The given aldehyde is treated with sodium hydroxide, to produce
The complete, detailed mechanism and the major organic product for the given reaction is as shown below:
The complete, detailed mechanism and the major organic product for given reaction is drawn on the basis of intramolecular aldol condensation reaction.
(d)
Interpretation:
The complete, detailed mechanism and the major organic product for given reaction is to be drawn.
Concept introduction:
When ketone is treated with strong base like LDA, the product enolate anion is formed. In Step 1, LDA deprotonates the
Answer to Problem 18.68P
The complete, detailed mechanism and the major organic product for given reaction is as shown below,
Explanation of Solution
The given reaction is
Firstly, the given ketone is treated with LDA, to produce
The complete, detailed mechanism and the major organic product for given reaction is as shown below,
The complete, detailed mechanism and the major organic product for given reaction is drawn by aldol addition reaction followed by dehydration of
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Chapter 18 Solutions
Organic Chemistry: Principles and Mechanisms (Second Edition)
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