(a)
Interpretation:
The validation of the fact that the given ester cannot be synthesized by malonic ester synthesis is to be stated with an explanation.
Concept introduction:
Deprotonation of malonic ester giveenolate ion. This enolate ion is alkylated by an unhindered
(b)
Interpretation:
The acid-base reaction between LDA and the given ester is to be stated and the direction of equilibrium is to be predicted.
Concept introduction:
LDA (Lithium Di-isopropyl Amide) is a strong base with a molecular formula,
(c)
Interpretation:
The method of preparation of given compound using malonic ester synthesis is to be stated.
Concept introduction:
Deprotonation of malonic ester give enolate ion. This enolate ion is alkylated by an unhindered alkyl halide, tosylates or any other electrophilic species through displacement to give alkylated diethyl malonate. It will undergo hydrolysis to give substituted acetic acid.
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Organic Chemistry (9th Edition)
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